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- NCIT_C39147 NCIT_NHC0 "C39147" @default.
- NCIT_C39147 NCIT_P106 "Functional Concept" @default.
- NCIT_C39147 NCIT_P108 "Calpain-2 Cell Motility Pathway" @default.
- NCIT_C39147 NCIT_P207 "C1516153" @default.
- NCIT_C39147 NCIT_P216 "h_mCalpainPathway" @default.
- NCIT_C39147 NCIT_P325 "The mammalian calpain gene family currently contains 13 distinct large subunit products most of which complex with one of two smaller 30kDa subunits. One of the most carefully studied functions of the calpains is the regulation of integrin-mediated cell migration. Calpains digest the links between the actin cytoskeleton and several focal adhesion complex proteins; talin, paxillin and focal adhesion kinase. The release from the focal adhesion complex facilitates migration. Calpastatin is an inhibitor expressed in most cells. Calpastatin binds the four inhibitory domains of calpain. Release from calpastatin does not activate calpain. Activation requires additional signaling, coactivators, and an appropriate calcium concentration. During cell migration calpain1 (mu-calpain) acts at the leading edge as a response to integrin signals or calcium fluctuations due to the stretch activated calcium channels. Calpain1 cleaves the target proteins, talin, ezrin, paxillin, and the cytoplasmic tail of the integrins B1(a) and B3(b) to release the adhesion and form new adhesions. Calpain2 (M-calpain) is believed to be membrane bound and functions at the trailing edge of the migrating cell to cleave the integrins in response to growth factor receptor signals. PKA functions to down regulate or inhibit calpain2. In Alzheimer's disease, amyloid peptides interfere with calpain activity causing a mislocalization of cdk5. Deregulated cdk5 hyperphosphorylates tau promoting cell death in neurons. Mutations in the muscle specific calpain p94 lead to Limb Girdle muscular dystrophy 2A (LGMD2A). Over activity of calpains due to elevated calcium leads to tissue damage in the heart and brain. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39147 NCIT_P366 "Calpain_Cell_Motility_Pathway" @default.
- NCIT_C39147 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39147 normalizedInformationContent "76.863042570845906" @default.
- NCIT_C39147 referenceCount "33" @default.
- NCIT_C39147 hasExactSynonym "Calpain-2 Cell Motility Pathway" @default.
- NCIT_C39147 hasExactSynonym "M-Calpain Cell Motility Pathway" @default.
- NCIT_C39147 hasExactSynonym "mCalpain and friends in Cell motility" @default.
- NCIT_C39147 type Class @default.
- NCIT_C39147 isDefinedBy ncit.owl @default.
- NCIT_C39147 label "Calpain-2 Cell Motility Pathway" @default.
- NCIT_C39147 subClassOf NCIT_C20633 @default.
- NCIT_C39147 subClassOf NCIT_C39147 @default.
- NCIT_C39147 subClassOf NCIT_C39703 @default.