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- NCIT_C39154 NCIT_NHC0 "C39154" @default.
- NCIT_C39154 NCIT_P106 "Functional Concept" @default.
- NCIT_C39154 NCIT_P108 "Mitochondria in Apoptotic Signaling Pathway" @default.
- NCIT_C39154 NCIT_P207 "C1513340" @default.
- NCIT_C39154 NCIT_P216 "h_mitochondriaPathway" @default.
- NCIT_C39154 NCIT_P325 "Mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein in electron transport, is released from mitochondria in response to apoptotic signals, and activates Apaf-1, a protease released from mitochondria. Activated Apaf-1 activates caspase-9 and the rest of the caspase pathway. Smac/DIABLO is released from mitochondria and inhibits IAP proteins that normally interact with caspase-9 to inhibit apoptosis. Apoptosis regulation by Bcl-2 family proteins occurs as family members form complexes that enter the mitochondrial membrane, regulating the release of cytochrome c and other proteins. TNF family receptors that cause apoptosis directly activate the caspase cascade, but can also activate Bid, a Bcl-2 family member, which activates mitochondria-mediated apoptosis. Bax, another Bcl-2 family member, is activated by this pathway to localize to the mitochondrial membrane and increase its permeability, releasing cytochrome c and other mitochondrial proteins. Bcl-2 and Bcl-xL prevent pore formation, blocking apoptosis. AIF (apoptosis inducing factor) is another mitochondrial factor that is released into the cytoplasm to induce apoptosis. AIF-induced apoptosis is important during development but is not caspase dependent. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39154 NCIT_P366 "Mitochondria_in_Apoptotic_Signaling_Pathway" @default.
- NCIT_C39154 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39154 normalizedInformationContent "76.287274181997702" @default.
- NCIT_C39154 referenceCount "36" @default.
- NCIT_C39154 hasExactSynonym "Mitochondria in Apoptotic Signaling Pathway" @default.
- NCIT_C39154 hasExactSynonym "Role of Mitochondria in Apoptotic Signaling" @default.
- NCIT_C39154 type Class @default.
- NCIT_C39154 isDefinedBy ncit.owl @default.
- NCIT_C39154 label "Mitochondria in Apoptotic Signaling Pathway" @default.
- NCIT_C39154 subClassOf NCIT_C17132 @default.
- NCIT_C39154 subClassOf NCIT_C19779 @default.
- NCIT_C39154 subClassOf NCIT_C20633 @default.
- NCIT_C39154 subClassOf NCIT_C39154 @default.
- NCIT_C39154 subClassOf NCIT_C39699 @default.