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- NCIT_C39155 NCIT_NHC0 "C39155" @default.
- NCIT_C39155 NCIT_P106 "Functional Concept" @default.
- NCIT_C39155 NCIT_P108 "Signal Dependent Regulation of Myogenesis Pathway" @default.
- NCIT_C39155 NCIT_P207 "C1519307" @default.
- NCIT_C39155 NCIT_P216 "h_MITRPathway" @default.
- NCIT_C39155 NCIT_P325 "The differentiation of muscle cells is regulated by many factors, including the MyoD/MEF2 family of transcription factors. The MyoD/MEF2 dimer binds to promoters to activate genes involved in muscle cell differentiation. One of the factors that regulates the role of MyoD/MEF2 in myogenesis is the protein MEF2-interacting transcription repressor (MITR), a transcriptional repressor. When MITR is bound to MEF2, myogenesis genes are repressed rather than being activated. The transcriptional repression by MITR occurs in part at least through interaction with the CtBP (carboxy-terminal binding protein) corepressor. The inhibitory activity of MITR is itself regulated by the calmodulin dependent protein kinase CAMK. When CAMK is activated by factors such as IGF-1, it phosphorylates two specific residues in MITR, ser218 and ser448. Phosphorylated MITR does not bind to MEF2, but does bind to the protein 14-3-3, helping to block the repression of myogenesis. CAMK also plays a role in myogenesis through phosphorylation of histone deacetylase (HDAC), in which HDAC alters chromatin to repress myogenesis. Like MITR, phosphorylation of HDAC removes the repression, allowing myogenesis to continue. MITR shares sequence homology with HDAC, but itself lacks the enzyme motif. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39155 NCIT_P366 "Signal_Dependent_Regulation_of_Myogenesis_Pathway" @default.
- NCIT_C39155 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39155 normalizedInformationContent "87.123597049860606" @default.
- NCIT_C39155 referenceCount "7" @default.
- NCIT_C39155 hasExactSynonym "Signal Dependent Regulation of Myogenesis Pathway" @default.
- NCIT_C39155 hasExactSynonym "Signal Dependent Regulation of Myogenesis by Corepressor MITR" @default.
- NCIT_C39155 type Class @default.
- NCIT_C39155 isDefinedBy ncit.owl @default.
- NCIT_C39155 label "Signal Dependent Regulation of Myogenesis Pathway" @default.
- NCIT_C39155 subClassOf NCIT_C20633 @default.
- NCIT_C39155 subClassOf NCIT_C39155 @default.
- NCIT_C39155 subClassOf NCIT_C39704 @default.