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- NCIT_C39158 NCIT_NHC0 "C39158" @default.
- NCIT_C39158 NCIT_P106 "Functional Concept" @default.
- NCIT_C39158 NCIT_P108 "MTA3 Pathway" @default.
- NCIT_C39158 NCIT_P207 "C1518143" @default.
- NCIT_C39158 NCIT_P216 "h_mta3Pathway" @default.
- NCIT_C39158 NCIT_P325 "Approximately 30% of breast carcinomas lack ER expression. Presumably, these breast cancers become estrogen independent through genetic alterations that bypass the requirement for ER-dependent stimulation of cell proliferation. As such, estrogen receptor is a key regulator of proliferation and differentiation in mammary epithelia and represents a crucial prognostic indicator and therapeutic target in breast cancer. Mechanistically, estrogen receptor induces changes in gene expression through direct gene activation of a number of genes (e.g., cathepsin D, HSP27, alpha-tubulin, glyceraldehyde-3-phosphatase, Pdzk1, Greb) and also through the biological functions of target loci. The product of human MTA3 has been identified as an estrogen-dependent component of the Mi-2/NuRD transcriptional corepressor in breast epithelial cells and demonstrates that MTA3 constitutes a key component of an estrogen-dependent pathway regulating growth and differentiation. The absence of estrogen receptor or of MTA3 leads to aberrant expression of the transcriptional repressor Snail, a master regulator of epithelial to mesenchymal transitions. Aberrant Snail expression results in loss of expression of the cell adhesion molecule E-cadherin, an event associated with changes in epithelial architecture and invasive growth. MTA3 is the mechanistic link between estrogen receptor status and invasive growth of breast cancers. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39158 NCIT_P366 "MTA3_Pathway" @default.
- NCIT_C39158 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39158 normalizedInformationContent "80.516169887777039" @default.
- NCIT_C39158 referenceCount "19" @default.
- NCIT_C39158 hasExactSynonym "Downregulated of MTA-3 in ER-negative Breast Tumors" @default.
- NCIT_C39158 hasExactSynonym "MTA3 Pathway" @default.
- NCIT_C39158 type Class @default.
- NCIT_C39158 isDefinedBy ncit.owl @default.
- NCIT_C39158 label "MTA3 Pathway" @default.
- NCIT_C39158 subClassOf NCIT_C20633 @default.
- NCIT_C39158 subClassOf NCIT_C39158 @default.
- NCIT_C39158 subClassOf NCIT_C39701 @default.