Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C39159> ?p ?o ?g. }
Showing items 1 to 25 of
25
with 100 items per page.
- NCIT_C39159 IAO_0000115 "A signal transduction pathway described by the BioCarta database, where exposure of cells to nutrients, growth factors and other mitogens activate signaling through binding to various cell surface receptors and ultimately lead to the activation of serine/threonine-protein kinase mTOR. This pathway plays a role in transcriptional regulation of a number of genes involved in cellular growth and survival." @default.
- NCIT_C39159 NCIT_NHC0 "C39159" @default.
- NCIT_C39159 NCIT_P106 "Functional Concept" @default.
- NCIT_C39159 NCIT_P107 "mTOR Signaling Pathway" @default.
- NCIT_C39159 NCIT_P108 "mTOR Signaling Pathway BioCarta" @default.
- NCIT_C39159 NCIT_P207 "C1515673" @default.
- NCIT_C39159 NCIT_P216 "h_mTORPathway" @default.
- NCIT_C39159 NCIT_P322 "CTRP" @default.
- NCIT_C39159 NCIT_P325 "mTOR (mammalian target of rapamycin) appears to play a central role in signaling caused by nutrients and mitogens such as growth factors to regulate translation. The drug rapamycin acts on mammalian cells through the mTOR protein kinase, also known as FRAP. When bound to the immunophilin binding protein FKBP12, rapamycin inhibits mTOR kinase activity and has immunosuppressant activity. Rapamycin and the mTOR inhibitor CCI-779 are being tested as anti-cancer agents, acting to block mitogenic signaling. Recently, mTOR was also found to act as an ATP sensor to regulate cell growth. Upstream activation of PI 3 kinase activity that leads to oncogenic transformation can be blocked by inhibition of mTOR by rapamycin. Growth factor receptors first stimulate PI 3 kinase, and through inositol phosphates activate PDK-1 and AKT (protein kinase B). AKT phosphorylates mTOR. The phosphorylation of p70S6K and 4EBP by mTOR and the phosphorylation downstream of RPS6 and EIF-4B stimulate translational initiation and contribute to cell growth. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39159 NCIT_P366 "mTOR_Signaling_Pathway" @default.
- NCIT_C39159 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39159 normalizedInformationContent "77.066663625307044" @default.
- NCIT_C39159 referenceCount "32" @default.
- NCIT_C39159 hasExactSynonym "mTOR Signaling Pathway BioCarta" @default.
- NCIT_C39159 hasExactSynonym "mTOR Signaling Pathway" @default.
- NCIT_C39159 hasExactSynonym "mTOR Signaling Pathwayc" @default.
- NCIT_C39159 inSubset NCIT_C116977 @default.
- NCIT_C39159 inSubset NCIT_C142799 @default.
- NCIT_C39159 inSubset NCIT_C142800 @default.
- NCIT_C39159 type Class @default.
- NCIT_C39159 isDefinedBy ncit.owl @default.
- NCIT_C39159 label "mTOR Signaling Pathway BioCarta" @default.
- NCIT_C39159 subClassOf NCIT_C17132 @default.
- NCIT_C39159 subClassOf NCIT_C20633 @default.
- NCIT_C39159 subClassOf NCIT_C39159 @default.