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- NCIT_C39160 NCIT_NHC0 "C39160" @default.
- NCIT_C39160 NCIT_P106 "Functional Concept" @default.
- NCIT_C39160 NCIT_P108 "Myosin Phosphatase Pathway" @default.
- NCIT_C39160 NCIT_P207 "C1513801" @default.
- NCIT_C39160 NCIT_P216 "h_myosinPathway" @default.
- NCIT_C39160 NCIT_P325 "The phosphorylation of myosin affects its role in smooth muscle contraction, platelet formation, and possibly other processes. Phosphorylation by myosin light chain kinase (MLCK) increases myosin activity and dephosphorylation by myosin phosphatase decreases myosin activity. CPI, a factor that binds to and inhibits myosin phosphatase, is a target of phosphorylation by PKC and PKN. The inhibitory activity of CPI is regulated by its own phosphorylation state; when CPI is phosphorylated, its inhibitory activity is increased. The activation of signal transduction cascades such as GPCR pathways can lead to activation of PKC, phosphorylation of CPI, inhibition of myosin phosphatase, increased myosin phosphorylation, and increased smooth muscle contraction or platelet release. The action of histamine in vasoconstriction, for example, may be mediated by activation of PKC through the histamine receptor, resulting in phosphorylation of CPI-17, increased inhibition of myosin phosphatase, and increased smooth muscle contraction. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39160 NCIT_P366 "Myosin_Phosphatase_Pathway" @default.
- NCIT_C39160 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39160 normalizedInformationContent "80.516169887777039" @default.
- NCIT_C39160 referenceCount "19" @default.
- NCIT_C39160 hasExactSynonym "Myosin Pathway" @default.
- NCIT_C39160 hasExactSynonym "Myosin Phosphatase Pathway" @default.
- NCIT_C39160 hasExactSynonym "PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase" @default.
- NCIT_C39160 type Class @default.
- NCIT_C39160 isDefinedBy ncit.owl @default.
- NCIT_C39160 label "Myosin Phosphatase Pathway" @default.
- NCIT_C39160 subClassOf NCIT_C19779 @default.
- NCIT_C39160 subClassOf NCIT_C20633 @default.
- NCIT_C39160 subClassOf NCIT_C39160 @default.
- NCIT_C39160 subClassOf NCIT_C91822 @default.