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- NCIT_C39171 NCIT_NHC0 "C39171" @default.
- NCIT_C39171 NCIT_P106 "Functional Concept" @default.
- NCIT_C39171 NCIT_P108 "Protein Import into Nucleus Pathway" @default.
- NCIT_C39171 NCIT_P207 "C1514547" @default.
- NCIT_C39171 NCIT_P216 "h_npcPathway" @default.
- NCIT_C39171 NCIT_P325 "Nuclear pore complexes (NPCs) are large proteinaceous assemblies that provide the only known portals for exchanging macromolecules between the nucleus and cytoplasm. This includes the movement of small molecules and the selective, facilitated transport of large proteins and RNAs. Faithful, continuous NPC assembly is key for maintaining normal physiological function and is closely tied to proper cell division. One of the unexpected developments during the past decade was the realization that the NPC itself probably does not function primarily as a gating mechanism or by directly transporting cargo macromolecules between the nuclear and cytoplasmic compartments. Instead, nuclear trafficking relies on a range of soluble components. Transport factors bind their cargo in one compartment and then move through the NPCs to the other compartment, where the cargo is released. The transport factor then recycles back through the NPC to participate in another round of transport. In many instances, this process is orchestrated by the Ras-superfamily GTPase Ran. Bischoff et al. describe in detail how the nucleotide state of Ran is controlled by its nuclear guanine-nucleotide-exchange factor (RCC1) and cytoplasmic GTPase-activating protein (RanGAP). The nucleotide state of Ran is crucial to defining the interactions between transport factors, their cargoes and nucleoporins, and is fundamental to the sorting mechanism that defines the directionality of transport. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39171 NCIT_P366 "Protein_Import_into_Nucleus_Pathway" @default.
- NCIT_C39171 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39171 normalizedInformationContent "82.080392758357064" @default.
- NCIT_C39171 referenceCount "15" @default.
- NCIT_C39171 hasExactSynonym "Mechanism of Protein Import into the Nucleus" @default.
- NCIT_C39171 hasExactSynonym "Protein Import into Nucleus Pathway" @default.
- NCIT_C39171 type Class @default.
- NCIT_C39171 isDefinedBy ncit.owl @default.
- NCIT_C39171 label "Protein Import into Nucleus Pathway" @default.
- NCIT_C39171 subClassOf NCIT_C19779 @default.
- NCIT_C39171 subClassOf NCIT_C20633 @default.
- NCIT_C39171 subClassOf NCIT_C39171 @default.
- NCIT_C39171 subClassOf NCIT_C91760 @default.