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- NCIT_C39178 NCIT_NHC0 "C39178" @default.
- NCIT_C39178 NCIT_P106 "Functional Concept" @default.
- NCIT_C39178 NCIT_P108 "p38 MAPK Signaling Pathway BioCarta" @default.
- NCIT_C39178 NCIT_P207 "C1515678" @default.
- NCIT_C39178 NCIT_P216 "h_p38mapkPathway" @default.
- NCIT_C39178 NCIT_P325 "p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, and Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/5. The p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, Max/Myc complex, MEF-2, ELK-1, and indirectly CREB via activation of MSK1. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39178 NCIT_P366 "p38_MAPK_Signaling_Pathway" @default.
- NCIT_C39178 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39178 normalizedInformationContent "72.377402634338907" @default.
- NCIT_C39178 referenceCount "65" @default.
- NCIT_C39178 hasExactSynonym "p38 MAPK Signaling Pathway BioCarta" @default.
- NCIT_C39178 hasExactSynonym "p38 MAPK Signaling Pathway" @default.
- NCIT_C39178 type Class @default.
- NCIT_C39178 isDefinedBy ncit.owl @default.
- NCIT_C39178 label "p38 MAPK Signaling Pathway BioCarta" @default.
- NCIT_C39178 subClassOf NCIT_C17132 @default.
- NCIT_C39178 subClassOf NCIT_C20633 @default.
- NCIT_C39178 subClassOf NCIT_C39178 @default.