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- NCIT_C39186 NCIT_NHC0 "C39186" @default.
- NCIT_C39186 NCIT_P106 "Functional Concept" @default.
- NCIT_C39186 NCIT_P108 "Pelp1 Estrogen Receptor Pathway" @default.
- NCIT_C39186 NCIT_P207 "C1518940" @default.
- NCIT_C39186 NCIT_P216 "h_pelp1Pathway" @default.
- NCIT_C39186 NCIT_P325 "Proline-, glutamic acid-, leucine-rich protein 1 (Pelp1 or modulator of nongenomic activity of estrogen, MNAR) is a recently discovered transmitter of estrogen signals. The receptors for estrogen (ER), progestin (PR), androgen (AR) and others are steroid hormone receptors, which are part of a large family of ligand-inducible transcription factors. It has been established that estrogen has at least two courses of action termed classical or genomic and nongenomic. The classical activation cascade is well known. The nongenomic or nontranscriptional activation cascade for the estrogen receptor was determined based on the rapid response times observed for the activation of the MAPK cascade and other cell proliferation effects. The mechanism was believed to involve a membrane bound ER but attempts to isolate such a protein have not been successful. A second possibility would involve a scaffold protein that interacts with ER. Pelp1 appears to fit the second scenario. Pelp1 was first isolated as a coactivator of transcription for ER-alpha. It was observed that Pelp1 was expressed at levels 3-5 times normal in breast tumors. Several breast cancer cell lines have been shown to express Pelp1. Like many nuclear hormone receptors Pelp1 also interacts with Cbp and p300. More recently it has been demonstrated that Pelp1 mediates the interaction of ER and Src leading to the activation of the Mitogen Activated Protein Kinases Erk1 and Erk2. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39186 NCIT_P366 "Pelp1_Estrogen_Receptor_Pathway" @default.
- NCIT_C39186 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39186 normalizedInformationContent "82.080392758357064" @default.
- NCIT_C39186 referenceCount "15" @default.
- NCIT_C39186 hasExactSynonym "Pelp1 Estrogen Receptor Pathway" @default.
- NCIT_C39186 hasExactSynonym "Pelp1 Modulation of Estrogen Receptor Activity" @default.
- NCIT_C39186 type Class @default.
- NCIT_C39186 isDefinedBy ncit.owl @default.
- NCIT_C39186 label "Pelp1 Estrogen Receptor Pathway" @default.
- NCIT_C39186 subClassOf NCIT_C17132 @default.
- NCIT_C39186 subClassOf NCIT_C20633 @default.
- NCIT_C39186 subClassOf NCIT_C39186 @default.