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- NCIT_C39193 NCIT_NHC0 "C39193" @default.
- NCIT_C39193 NCIT_P106 "Functional Concept" @default.
- NCIT_C39193 NCIT_P108 "Phospholipase C-Epsilon Signaling Pathway" @default.
- NCIT_C39193 NCIT_P207 "C1519053" @default.
- NCIT_C39193 NCIT_P216 "h_plcePathway" @default.
- NCIT_C39193 NCIT_P325 "Proposed model for b2-AR- and prostanoid-receptor-mediated PLC and calcium signaling. Receptors coupling to Gs stimulate AC, resulting in elevated cAMP levels and activation of Epac1. Epac1 then catalyses GTP-loading on Rap2B, which leads to PLC-e activation. The proposed pathway may involve additional signaling components to attain PLC stimulation. The action of cAMP seems to be independent of PKA; instead, the cAMP-activated Rap-GEF Epac seems to serve as a cAMP effector, inducing GTP loading and, hence, activation of Rap2B, which then leads to specific activation of PLC-e, which has been shown to interact with Rap GTPases. It is an attractive hypothesis, therefore, that the Rap-dependent PLC and calcium signaling pathway reported here is not restricted to Gs-and AC-coupled receptors, such as the b2-AR and the prostanoid receptor, but could be used by other receptors as well. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39193 NCIT_P366 "Phospholipase_C-Epsilon_Signaling_Pathway" @default.
- NCIT_C39193 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39193 normalizedInformationContent "80.873941456936294" @default.
- NCIT_C39193 referenceCount "18" @default.
- NCIT_C39193 hasExactSynonym "Phospholipase C-Epsilon Signaling Pathway" @default.
- NCIT_C39193 hasExactSynonym "Phospholipase C-epsilon pathway" @default.
- NCIT_C39193 type Class @default.
- NCIT_C39193 isDefinedBy ncit.owl @default.
- NCIT_C39193 label "Phospholipase C-Epsilon Signaling Pathway" @default.
- NCIT_C39193 subClassOf NCIT_C17132 @default.
- NCIT_C39193 subClassOf NCIT_C20633 @default.
- NCIT_C39193 subClassOf NCIT_C39193 @default.