Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C39217> ?p ?o ?g. }
Showing items 1 to 21 of
21
with 100 items per page.
- NCIT_C39217 NCIT_NHC0 "C39217" @default.
- NCIT_C39217 NCIT_P106 "Functional Concept" @default.
- NCIT_C39217 NCIT_P107 "Ras Signaling Pathway" @default.
- NCIT_C39217 NCIT_P108 "Ras Signaling Pathway" @default.
- NCIT_C39217 NCIT_P207 "C1514731" @default.
- NCIT_C39217 NCIT_P216 "h_rasPathway" @default.
- NCIT_C39217 NCIT_P322 "CTRP" @default.
- NCIT_C39217 NCIT_P325 "Ras activates many signaling cascades. Here we illustrate some of the well-characterized cascades in a generic compilation of effector molecules. The effectors mediate Ras stimulation to a diverse set of cellular signals. Many of these signals are interpreted differently depending on the cell type or microenvironment receiving the stimulus. Not all of these effectors are activated in any given cell type. The primary method of activation is to promote the translocation of the molecule to the plasma membrane where additional interactions lead to the activation of the molecule. RalGDS is a Guanine Exchange Factor (GEF) for Ral but also has other independent functions. RalGDS activates RalA/B-related small GTPases. RalBP1 is a GTPase activating protein that leads to the inhibition of the Rac and CDC42 GTPases. Ral can also interact with phospholipase D1 (PLD1) that can also be activated by RhoA. Ras stimulation of the lipid kinase activity of PI3K occurs through an interaction with the p110 catalytic subunit. PI3K phosphorylates the D3 position of phosphatidylinositides. In this example Pip2 is converted to PIP3. PIP3 stimulates the AKT/PKB kinase and several of the Rac-GEFs such as Sos1 AND Vav. AKT activation inhibits apoptosis by inhibiting the actions of Bad, Caspase 9, and AFX. AKT further hinders apoptosis by phosphorylating the IkB repressor of NFkB. Stimulus of Rac causes, among other things, the activation of NFkB. Ras also stimulates the mitogen-activated kinases ERK1/2 via the Raf1 cascade. The Erk kinases translocate to the nucleus where they phosphorylate various transcription factors such as ELK1. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39217 NCIT_P366 "Ras_Signaling_Pathway" @default.
- NCIT_C39217 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39217 normalizedInformationContent "73.363595225044847" @default.
- NCIT_C39217 referenceCount "56" @default.
- NCIT_C39217 hasExactSynonym "Ras Signaling Pathway" @default.
- NCIT_C39217 inSubset NCIT_C116977 @default.
- NCIT_C39217 inSubset NCIT_C142799 @default.
- NCIT_C39217 type Class @default.
- NCIT_C39217 isDefinedBy ncit.owl @default.
- NCIT_C39217 label "Ras Signaling Pathway" @default.
- NCIT_C39217 subClassOf NCIT_C17132 @default.
- NCIT_C39217 subClassOf NCIT_C20633 @default.
- NCIT_C39217 subClassOf NCIT_C39217 @default.