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- NCIT_C39239 NCIT_NHC0 "C39239" @default.
- NCIT_C39239 NCIT_P106 "Functional Concept" @default.
- NCIT_C39239 NCIT_P108 "Stathmin Pathway" @default.
- NCIT_C39239 NCIT_P207 "C1514959" @default.
- NCIT_C39239 NCIT_P216 "h_stathminPathway" @default.
- NCIT_C39239 NCIT_P325 "Stathmin is a ubiquitous, cytosolic 19-kDa protein, that is phosphorylated on up to four sites in response to many regulatory signals within cells. Its molecular characterization indicates a functional organization including an N-terminal regulatory domain that bears the phosphorylation sites linked to a putative alpha-helical binding domain predicted to participate in coiled-coil, protein-protein interactions. In addition to the protein kinases that phosphorylate Stathmin such as CaMK, MAPK, p34cdc2, PKA, a few other proteins have been suggested to interact with stathmin in vivo. One of them was identified as BiP, a member of the hsp70 heat-shock protein family. Another is a previously unidentified, putative serine/threonine kinase, KIS, which might be regulated by stathmin or, more likely, be part of the kinases controlling its phosphorylation state. Finally, proteins CC1 and CC2, predicted to form alpha-helices participating in coiled-coil interacting structures. It has been suggest that the action of antimicrotubule drugs can be affected by stathmin in at least two ways: (a) altered drug binding; and (b) growth arrest at the G2 to M boundary. Mutant p53 breast cancers exhibiting high levels of stathmin may be resistant to antimicrotubule agents. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39239 NCIT_P366 "Stathmin_Pathway" @default.
- NCIT_C39239 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39239 normalizedInformationContent "77.718057547374755" @default.
- NCIT_C39239 referenceCount "29" @default.
- NCIT_C39239 hasExactSynonym "Stathmin Pathway" @default.
- NCIT_C39239 hasExactSynonym "Stathmin and breast cancer resistance to antimicrotubule agents" @default.
- NCIT_C39239 type Class @default.
- NCIT_C39239 isDefinedBy ncit.owl @default.
- NCIT_C39239 label "Stathmin Pathway" @default.
- NCIT_C39239 subClassOf NCIT_C19779 @default.
- NCIT_C39239 subClassOf NCIT_C20633 @default.
- NCIT_C39239 subClassOf NCIT_C39239 @default.