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- NCIT_C39248 NCIT_NHC0 "C39248" @default.
- NCIT_C39248 NCIT_P106 "Functional Concept" @default.
- NCIT_C39248 NCIT_P108 "Terc Regulation Pathway" @default.
- NCIT_C39248 NCIT_P207 "C1515271" @default.
- NCIT_C39248 NCIT_P216 "h_tercPathway" @default.
- NCIT_C39248 NCIT_P325 "Telomerase is an enzyme that replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells that have an unlimited replicative capacity, such as male germ cells and the majority of human cancers, have high levels of telomerase activity. The level and frequency of telomerase activity in more than 85% of all cancers highlights the critical role telomerase plays in tumor progression. Telomerase activation is the most common general marker for a cancer cell to date making it an attractive target for new cancer diagnostics and therapeutics. Human telomerase activity can be reconstituted in vitro by the essential RNA subunit, hTERC, and the catalytic protein component coded for by the hTERT gene. Both the human telomerase reverse transcriptase gene (hTERT) and the telomerase RNA gene (hTERC) are controlled at least in part at the transcriptional level. The hTERC gene is expressed at high levels in cancer cells, and is absent or at low levels in some normal tissues. (This definition may be outdated - see the DesignNote.)" @default.
- NCIT_C39248 NCIT_P366 "Terc_Regulation_Pathway" @default.
- NCIT_C39248 NCIT_P98 "The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/." @default.
- NCIT_C39248 normalizedInformationContent "85.460608731874885" @default.
- NCIT_C39248 referenceCount "9" @default.
- NCIT_C39248 hasExactSynonym "Overview of telomerase RNA component gene hTerc Transcriptional Regulation" @default.
- NCIT_C39248 hasExactSynonym "Terc Regulation Pathway" @default.
- NCIT_C39248 type Class @default.
- NCIT_C39248 isDefinedBy ncit.owl @default.
- NCIT_C39248 label "Terc Regulation Pathway" @default.
- NCIT_C39248 subClassOf NCIT_C19779 @default.
- NCIT_C39248 subClassOf NCIT_C20633 @default.
- NCIT_C39248 subClassOf NCIT_C39248 @default.