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- NCIT_C400 IAO_0000115 "A toxic protein complex isolated from Crotalus durissus terrificus (South American rattlesnake) venom that is comprised of a basic neurotoxic subunit with phospholipase A2 (PLA2) activity and an acidic non-enzymatic, non-toxic subunit called crotapotin, with anticoagulant and immunomodulatory activities. The PLA2 subunit of crotoxin hydrolyzes the acyl groups in phosphoglycerides, acts as an anticoagulant by inhibiting the prothrombinase activity of coagulation factor Xa (F10a) and increases chloride-dependent current modulated by the cystic fibrosis transmembrane conductance regulator (CFTR). The PLA2 subunit may also metabolize eicosanoids, forming products that cause sequestration of lymphocytes in the lymph nodes and inhibit the spreading and phagocytic activity of macrophages. Crotoxin down-modulates the immune system, leading to the inhibition of both humoral and cellular immune responses." @default.
- NCIT_C400 NCIT_NHC0 "C400" @default.
- NCIT_C400 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C400 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C400 NCIT_P108 "Crotoxin" @default.
- NCIT_C400 NCIT_P207 "C0010377" @default.
- NCIT_C400 NCIT_P210 "9007-40-3" @default.
- NCIT_C400 NCIT_P329 "42541" @default.
- NCIT_C400 NCIT_P330 "42541" @default.
- NCIT_C400 NCIT_P366 "Crotoxin" @default.
- NCIT_C400 NCIT_P399 "42541" @default.
- NCIT_C400 normalizedInformationContent "100" @default.
- NCIT_C400 referenceCount "1" @default.
- NCIT_C400 hasExactSynonym "CTX" @default.
- NCIT_C400 hasExactSynonym "Crotoxin" @default.
- NCIT_C400 hasExactSynonym "Ctrx" @default.
- NCIT_C400 inSubset NCIT_C176424 @default.
- NCIT_C400 type Class @default.
- NCIT_C400 isDefinedBy ncit.owl @default.
- NCIT_C400 label "Crotoxin" @default.
- NCIT_C400 subClassOf NCIT_C1908 @default.
- NCIT_C400 subClassOf NCIT_C1909 @default.
- NCIT_C400 subClassOf NCIT_C1932 @default.
- NCIT_C400 subClassOf NCIT_C210 @default.
- NCIT_C400 subClassOf NCIT_C2140 @default.
- NCIT_C400 subClassOf NCIT_C2554 @default.
- NCIT_C400 subClassOf NCIT_C308 @default.
- NCIT_C400 subClassOf NCIT_C400 @default.
- NCIT_C400 subClassOf NCIT_C688 @default.
- NCIT_C400 subClassOf NCIT_C894 @default.