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- NCIT_C403 IAO_0000115 "The hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. Cytarabine agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Compared to cytarabine, a more prolonged, consistent cytarabine-mediated therapeutic effect may be achieved with ancitabine because of the slow hydrolytic conversion of ancitabine to cytarabine." @default.
- NCIT_C403 NCIT_A32 NCIT_C1909 @default.
- NCIT_C403 NCIT_A6 NCIT_C80636 @default.
- NCIT_C403 NCIT_A7 NCIT_C449 @default.
- NCIT_C403 NCIT_NHC0 "C403" @default.
- NCIT_C403 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C403 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C403 NCIT_P108 "Ancitabine Hydrochloride" @default.
- NCIT_C403 NCIT_P175 "145668" @default.
- NCIT_C403 NCIT_P207 "C0010557" @default.
- NCIT_C403 NCIT_P210 "10212-25-6" @default.
- NCIT_C403 NCIT_P319 "3T6920M469" @default.
- NCIT_C403 NCIT_P322 "FDA" @default.
- NCIT_C403 NCIT_P322 "GDC" @default.
- NCIT_C403 NCIT_P329 "39199" @default.
- NCIT_C403 NCIT_P330 "39199" @default.
- NCIT_C403 NCIT_P350 "C9H11N3O4.ClH" @default.
- NCIT_C403 NCIT_P366 "Ancitabine_Hydrochloride" @default.
- NCIT_C403 NCIT_P375 "Ancitabine Hydrochloride" @default.
- NCIT_C403 NCIT_P399 "39199" @default.
- NCIT_C403 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C403 referenceCount "3" @default.
- NCIT_C403 hasExactSynonym "6H-furo(2',3':4,5)oxazolo(3,2-a)pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,(2R(2alpha,3beta,3a beta,9a beta))" @default.
- NCIT_C403 hasExactSynonym "ANCITABINE HYDROCHLORIDE" @default.
- NCIT_C403 hasExactSynonym "Ancid" @default.
- NCIT_C403 hasExactSynonym "Ancitabine Hydrochloride" @default.
- NCIT_C403 hasExactSynonym "Ancitabine hydrochloride" @default.
- NCIT_C403 hasExactSynonym "Ancytabine Hydrochloride" @default.
- NCIT_C403 hasExactSynonym "CycloCMP Hydrochloride" @default.
- NCIT_C403 hasExactSynonym "CycloCMP hydrochloride" @default.
- NCIT_C403 hasExactSynonym "Cyclocytidine HCL" @default.
- NCIT_C403 hasExactSynonym "Cyclocytidine Hydrochloride" @default.
- NCIT_C403 hasExactSynonym "Cyclocytidine hydrochloride" @default.
- NCIT_C403 hasExactSynonym "Cyclocytidine" @default.
- NCIT_C403 hasExactSynonym "U-33, 624A" @default.
- NCIT_C403 inSubset NCIT_C128784 @default.
- NCIT_C403 inSubset NCIT_C157711 @default.
- NCIT_C403 inSubset NCIT_C157712 @default.
- NCIT_C403 inSubset NCIT_C176424 @default.
- NCIT_C403 inSubset NCIT_C177537 @default.
- NCIT_C403 inSubset NCIT_C63923 @default.
- NCIT_C403 type Class @default.
- NCIT_C403 isDefinedBy ncit.owl @default.
- NCIT_C403 label "Ancitabine Hydrochloride" @default.
- NCIT_C403 subClassOf NCIT_C1557 @default.
- NCIT_C403 subClassOf NCIT_C186664 @default.
- NCIT_C403 subClassOf NCIT_C1908 @default.
- NCIT_C403 subClassOf NCIT_C1909 @default.
- NCIT_C403 subClassOf NCIT_C272 @default.
- NCIT_C403 subClassOf NCIT_C274 @default.
- NCIT_C403 subClassOf NCIT_C403 @default.