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- NCIT_C41038 IAO_0000115 "Nuclear or cytoplasmic human Riboadenylate Transferases (Poly A Polymerase Family) catalyze template-independent post-transcriptional extension of the 3 prime end of an RNA strand by nonspecific and CPSF/AAUAAA-dependent polyadenylation activity during eukaryotic mRNA maturation. The N-terminal region appears required for nonspecific polymerase activity, while the N- and C-termini are required for specific polymerase activity. Specificity may occur through C-terminus interaction with CPSF, regulated by phosphorylation. The poly(A) reaction involves endoribonucleolytic pre-RNA cleavage at the poly(A) site and synthesis of the poly(A) tail. (NCI)" @default.
- NCIT_C41038 NCIT_NHC0 "C41038" @default.
- NCIT_C41038 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C41038 NCIT_P106 "Enzyme" @default.
- NCIT_C41038 NCIT_P108 "Riboadenylate Transferase" @default.
- NCIT_C41038 NCIT_P207 "C0032401" @default.
- NCIT_C41038 NCIT_P366 "Riboadenylate_Transferase" @default.
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- NCIT_C41038 NCIT_R54 NCIT_C16612 @default.
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- NCIT_C41038 NCIT_R54 NCIT_C25942 @default.
- NCIT_C41038 normalizedInformationContent "88.143637090998837" @default.
- NCIT_C41038 referenceCount "6" @default.
- NCIT_C41038 hasExactSynonym "Polynucleotide Adenylyltransferase" @default.
- NCIT_C41038 hasExactSynonym "Riboadenylate Transferase" @default.
- NCIT_C41038 type Class @default.
- NCIT_C41038 isDefinedBy ncit.owl @default.
- NCIT_C41038 label "Riboadenylate Transferase" @default.
- NCIT_C41038 subClassOf Baaeff53941a45a84e30c2076754aaad3 @default.
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- NCIT_C41038 subClassOf NCIT_C20636 @default.
- NCIT_C41038 subClassOf NCIT_C26548 @default.
- NCIT_C41038 subClassOf NCIT_C41038 @default.