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- NCIT_C415 IAO_0000115 "A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration." @default.
- NCIT_C415 NCIT_NHC0 "C415" @default.
- NCIT_C415 NCIT_P106 "Organic Chemical" @default.
- NCIT_C415 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C415 NCIT_P108 "Dapsone" @default.
- NCIT_C415 NCIT_P175 "6091" @default.
- NCIT_C415 NCIT_P207 "C0010980" @default.
- NCIT_C415 NCIT_P210 "80-08-0" @default.
- NCIT_C415 NCIT_P302 "Acne vulgaris; Dermatitis herpetiformis; Leprosy" @default.
- NCIT_C415 NCIT_P319 "8W5C518302" @default.
- NCIT_C415 NCIT_P322 "FDA" @default.
- NCIT_C415 NCIT_P325 "A drug used to treat acne. It is also used to treat other types of skin diseases and certain bacterial infections, such as leprosy. It blocks bacteria from making a substance that they need to grow. Dapsone is a type of antibacterial agent and a type of anti-inflammatory agent." @default.
- NCIT_C415 NCIT_P329 "40323" @default.
- NCIT_C415 NCIT_P330 "40323" @default.
- NCIT_C415 NCIT_P350 "C12H12N2O2S" @default.
- NCIT_C415 NCIT_P366 "Dapsone" @default.
- NCIT_C415 NCIT_P368 "CHEBI:4325" @default.
- NCIT_C415 NCIT_P399 "40323" @default.
- NCIT_C415 NCIT_R122 NCIT_C16484 @default.
- NCIT_C415 NCIT_R122 NCIT_C16486 @default.
- NCIT_C415 NCIT_R122 NCIT_C16554 @default.
- NCIT_C415 NCIT_R122 NCIT_C16865 @default.
- NCIT_C415 NCIT_R122 NCIT_C16946 @default.
- NCIT_C415 NCIT_R122 NCIT_C17021 @default.
- NCIT_C415 NCIT_R122 NCIT_C17573 @default.
- NCIT_C415 NCIT_R122 NCIT_C20027 @default.
- NCIT_C415 NCIT_R122 NCIT_C26548 @default.
- NCIT_C415 NCIT_R122 NCIT_C28459 @default.
- NCIT_C415 NCIT_R122 NCIT_C45999 @default.
- NCIT_C415 NCIT_R122 NCIT_C46000 @default.
- NCIT_C415 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C415 referenceCount "2" @default.
- NCIT_C415 hasExactSynonym "1358F" @default.
- NCIT_C415 hasExactSynonym "4,4'-Sulfonylbis[benzenamine]" @default.
- NCIT_C415 hasExactSynonym "4,4'-Sulfonylbisbenzamine" @default.
- NCIT_C415 hasExactSynonym "4,4'-Sulfonylbisbenzeneamine" @default.
- NCIT_C415 hasExactSynonym "4,4'-Sulfonyldianiline" @default.
- NCIT_C415 hasExactSynonym "Aczone" @default.
- NCIT_C415 hasExactSynonym "Avlosulfon" @default.
- NCIT_C415 hasExactSynonym "Bis(4-aminophenyl) sulfone" @default.
- NCIT_C415 hasExactSynonym "Bis(4-aminophenyl)sulfone" @default.
- NCIT_C415 hasExactSynonym "Croysulfone" @default.
- NCIT_C415 hasExactSynonym "DADPS" @default.
- NCIT_C415 hasExactSynonym "DAPSONE" @default.
- NCIT_C415 hasExactSynonym "DDS" @default.
- NCIT_C415 hasExactSynonym "Dapsone" @default.
- NCIT_C415 hasExactSynonym "Diphenasone" @default.
- NCIT_C415 hasExactSynonym "Disulone" @default.
- NCIT_C415 hasExactSynonym "Dumitone" @default.
- NCIT_C415 hasExactSynonym "Eporal" @default.
- NCIT_C415 hasExactSynonym "Novophone" @default.
- NCIT_C415 hasExactSynonym "Sulfona-MAE" @default.
- NCIT_C415 hasExactSynonym "Sulfona-Mae" @default.
- NCIT_C415 hasExactSynonym "Sulphadione" @default.
- NCIT_C415 hasExactSynonym "Undolac" @default.
- NCIT_C415 hasExactSynonym "dapsone" @default.
- NCIT_C415 inSubset NCIT_C173381 @default.
- NCIT_C415 inSubset NCIT_C173383 @default.
- NCIT_C415 inSubset NCIT_C176424 @default.
- NCIT_C415 inSubset NCIT_C63923 @default.
- NCIT_C415 type Class @default.
- NCIT_C415 isDefinedBy ncit.owl @default.
- NCIT_C415 label "Dapsone" @default.
- NCIT_C415 subClassOf B7a65720de4cc533fbf9d2453fe47c9fa @default.
- NCIT_C415 subClassOf Bb7212049978defbea9d97231af89a7fe @default.
- NCIT_C415 subClassOf Bc4445cf68617873363aa8b2769731380 @default.
- NCIT_C415 subClassOf Bc4a7d191418a3d8678ff75b74604ba5a @default.
- NCIT_C415 subClassOf Bcd2e2ec3b808387f00d983c6b53e1621 @default.
- NCIT_C415 subClassOf Be92569e32f69fa9d4bcf4a6cbbd15df0 @default.
- NCIT_C415 subClassOf NCIT_C1908 @default.
- NCIT_C415 subClassOf NCIT_C1909 @default.
- NCIT_C415 subClassOf NCIT_C254 @default.
- NCIT_C415 subClassOf NCIT_C415 @default.
- NCIT_C415 subClassOf NCIT_C849 @default.