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- NCIT_C427 IAO_0000115 "An L-glutamine diazo analogue amino acid antibiotic isolated from a species of the bacterial genus Streptomyces with potential antineoplastic activity. Diazooxonorleucine inhibits several glutamine-dependent biosynthetic pathways involved in the syntheses of D-glucosamine phosphate, purines and pyrimidines. This agent inhibits phosphate-activated glutaminase, a key enzyme for the synthesis of releasable glutamine, depleting cells of this essential amino acid and reducing their capacity to proliferate." @default.
- NCIT_C427 NCIT_A32 NCIT_C1909 @default.
- NCIT_C427 NCIT_NHC0 "C427" @default.
- NCIT_C427 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C427 NCIT_P106 "Antibiotic" @default.
- NCIT_C427 NCIT_P108 "Diazooxonorleucine" @default.
- NCIT_C427 NCIT_P175 "7365" @default.
- NCIT_C427 NCIT_P207 "C0012020" @default.
- NCIT_C427 NCIT_P210 "157-03-9" @default.
- NCIT_C427 NCIT_P319 "03J0H273KZ" @default.
- NCIT_C427 NCIT_P322 "FDA" @default.
- NCIT_C427 NCIT_P322 "GDC" @default.
- NCIT_C427 NCIT_P329 "39224" @default.
- NCIT_C427 NCIT_P330 "39224" @default.
- NCIT_C427 NCIT_P366 "Diazooxonorleucine" @default.
- NCIT_C427 NCIT_P375 "Diazooxonorleucine" @default.
- NCIT_C427 NCIT_P399 "39224" @default.
- NCIT_C427 normalizedInformationContent "100" @default.
- NCIT_C427 referenceCount "1" @default.
- NCIT_C427 hasExactSynonym "6-DIAZO-5-OXO-L-NORLEUCINE" @default.
- NCIT_C427 hasExactSynonym "6-diazo-5-oxo-L-norleucine" @default.
- NCIT_C427 hasExactSynonym "6-diazo-5-oxo-norleucine" @default.
- NCIT_C427 hasExactSynonym "DON" @default.
- NCIT_C427 hasExactSynonym "Diazooxonorleucine" @default.
- NCIT_C427 inSubset NCIT_C128784 @default.
- NCIT_C427 inSubset NCIT_C157711 @default.
- NCIT_C427 inSubset NCIT_C157712 @default.
- NCIT_C427 inSubset NCIT_C176424 @default.
- NCIT_C427 inSubset NCIT_C177537 @default.
- NCIT_C427 inSubset NCIT_C63923 @default.
- NCIT_C427 type Class @default.
- NCIT_C427 isDefinedBy ncit.owl @default.
- NCIT_C427 label "Diazooxonorleucine" @default.
- NCIT_C427 subClassOf NCIT_C1556 @default.
- NCIT_C427 subClassOf NCIT_C186664 @default.
- NCIT_C427 subClassOf NCIT_C1908 @default.
- NCIT_C427 subClassOf NCIT_C1909 @default.
- NCIT_C427 subClassOf NCIT_C2133 @default.
- NCIT_C427 subClassOf NCIT_C272 @default.
- NCIT_C427 subClassOf NCIT_C274 @default.
- NCIT_C427 subClassOf NCIT_C427 @default.
- NCIT_C427 subClassOf NCIT_C471 @default.