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- NCIT_C436 IAO_0000115 "The hydrochloride salt form of hydromorphone, the hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons." @default.
- NCIT_C436 NCIT_A6 NCIT_C62034 @default.
- NCIT_C436 NCIT_NHC0 "C436" @default.
- NCIT_C436 NCIT_P106 "Organic Chemical" @default.
- NCIT_C436 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C436 NCIT_P108 "Hydromorphone Hydrochloride" @default.
- NCIT_C436 NCIT_P175 "19046" @default.
- NCIT_C436 NCIT_P207 "C0700533" @default.
- NCIT_C436 NCIT_P210 "71-68-1" @default.
- NCIT_C436 NCIT_P302 "pain in opioid-tolerant patients." @default.
- NCIT_C436 NCIT_P319 "L960UP2KRW" @default.
- NCIT_C436 NCIT_P322 "CPTAC" @default.
- NCIT_C436 NCIT_P322 "FDA" @default.
- NCIT_C436 NCIT_P329 "574280" @default.
- NCIT_C436 NCIT_P330 "574280" @default.
- NCIT_C436 NCIT_P350 "C17H19NO3.HCl" @default.
- NCIT_C436 NCIT_P366 "Hydromorphone" @default.
- NCIT_C436 NCIT_P368 "CHEBI:5791" @default.
- NCIT_C436 NCIT_P399 "574280" @default.
- NCIT_C436 normalizedInformationContent "100" @default.
- NCIT_C436 referenceCount "1" @default.
- NCIT_C436 hasExactSynonym "Dilaudid HP" @default.
- NCIT_C436 hasExactSynonym "Dilaudid" @default.
- NCIT_C436 hasExactSynonym "Dimorphone" @default.
- NCIT_C436 hasExactSynonym "Exalgo" @default.
- NCIT_C436 hasExactSynonym "HYDROMORPHONE HYDROCHLORIDE" @default.
- NCIT_C436 hasExactSynonym "Hydromorphone Hydrochloride" @default.
- NCIT_C436 hasExactSynonym "Hydromorphone" @default.
- NCIT_C436 hasExactSynonym "Hydrostat" @default.
- NCIT_C436 hasExactSynonym "Hymorphan" @default.
- NCIT_C436 hasExactSynonym "Laudicon" @default.
- NCIT_C436 hasExactSynonym "Novolauden" @default.
- NCIT_C436 inSubset NCIT_C156952 @default.
- NCIT_C436 inSubset NCIT_C156953 @default.
- NCIT_C436 inSubset NCIT_C159412 @default.
- NCIT_C436 inSubset NCIT_C176424 @default.
- NCIT_C436 inSubset NCIT_C63923 @default.
- NCIT_C436 type Class @default.
- NCIT_C436 isDefinedBy ncit.owl @default.
- NCIT_C436 label "Hydromorphone Hydrochloride" @default.
- NCIT_C436 subClassOf NCIT_C1506 @default.
- NCIT_C436 subClassOf NCIT_C1908 @default.
- NCIT_C436 subClassOf NCIT_C1909 @default.
- NCIT_C436 subClassOf NCIT_C1913 @default.
- NCIT_C436 subClassOf NCIT_C1916 @default.
- NCIT_C436 subClassOf NCIT_C221 @default.
- NCIT_C436 subClassOf NCIT_C436 @default.
- NCIT_C436 subClassOf NCIT_C67413 @default.
- NCIT_C436 subClassOf NCIT_C718 @default.
- NCIT_C436 subClassOf NCIT_C78272 @default.