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- NCIT_C44394 IAO_0000115 "A colloidal solution containing ferric oxyhydroxide complexed with polymerized dextran, used as a form of parenteral iron-replacement therapy. Upon administration and absorption, the iron dextran complex is removed from plasma by the reticuloendothelial system which cleaves it into the components iron and dextran; ferric iron subsequently binds to transferrin or is stored as hemosiderin or ferritin. Transferrin-bound iron is transported in the plasma to the liver, spleen and bone marrow, where is it is incorporated into hemoglobin (Hgb) and to muscle where it is incorporated into myoglobin (Mb). Use of this agent circumvents the gastrointestinal adverse effects commonly encountered with the use of orally administered iron salt preparations. Because of cross-reactivity with antibodies targeted against polysaccharides similar to dextran, anaphylactic reactions may occur with this type of iron formulation." @default.
- NCIT_C44394 NCIT_NHC0 "C44394" @default.
- NCIT_C44394 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C44394 NCIT_P108 "Iron Dextran Complex" @default.
- NCIT_C44394 NCIT_P200 "C1505" @default.
- NCIT_C44394 NCIT_P207 "C0022092" @default.
- NCIT_C44394 NCIT_P310 "Retired_Concept" @default.
- NCIT_C44394 NCIT_P98 "Wed Aug 09 10:57:20 EDT 2023 - See 'Iron Dextran(C76837)'" @default.
- NCIT_C44394 normalizedInformationContent "100" @default.
- NCIT_C44394 referenceCount "1" @default.
- NCIT_C44394 hasExactSynonym "Iron Dextran Complex" @default.
- NCIT_C44394 type Class @default.
- NCIT_C44394 isDefinedBy ncit.owl @default.
- NCIT_C44394 label "Iron Dextran Complex" @default.
- NCIT_C44394 subClassOf NCIT_C28428 @default.
- NCIT_C44394 subClassOf NCIT_C44394 @default.
- NCIT_C44394 subClassOf NCIT_C83485 @default.
- NCIT_C44394 deprecated "true" @default.