Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C45796> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- NCIT_C45796 IAO_0000115 "TPMT*V3 Allele is a variant form of 34-kb 10-exon human TPMT Gene (TPMT Family), which encodes polymorphic monomeric 245-aa 28-kDa cytoplasmic Thiopurine S-Methyltransferase. Inhibited by S-adenosyl-L-homocysteine, TPMT catalyzes thiopurine S-methylation, an important metabolic pathway for thiopurine drugs such as 6-mercaptopurine. TPMT contains a variable number of 17/18 bp tandem repeats (VNTR), from 3-9 (*V3-*V9), within the GC-rich 5'-flanking TPMT promoter region that modulate the level of TPMT enzyme activity (to a smaller extent than ORF-based SNP effects). A decrease in gene expression is seen with increasing repeat numbers. TPMT*V3 contains 3 VNTR. TPMT activity is thought to be an important determinant of toxicity associated with thiopurine medications." @default.
- NCIT_C45796 NCIT_NHC0 "C45796" @default.
- NCIT_C45796 NCIT_P100 "187680" @default.
- NCIT_C45796 NCIT_P106 "Gene or Genome" @default.
- NCIT_C45796 NCIT_P108 "TPMT*V3 Allele" @default.
- NCIT_C45796 NCIT_P207 "C1710321" @default.
- NCIT_C45796 NCIT_P366 "TPMT_V3_Allele" @default.
- NCIT_C45796 NCIT_P96 "Thiopurine S-Methyltransferase" @default.
- NCIT_C45796 NCIT_R132 NCIT_C36391 @default.
- NCIT_C45796 NCIT_R132 NCIT_C3910 @default.
- NCIT_C45796 NCIT_R132 NCIT_C45576 @default.
- NCIT_C45796 NCIT_R132 NCIT_C45680 @default.
- NCIT_C45796 NCIT_R132 NCIT_C97926 @default.
- NCIT_C45796 NCIT_R153 NCIT_C36391 @default.
- NCIT_C45796 NCIT_R153 NCIT_C3910 @default.
- NCIT_C45796 NCIT_R153 NCIT_C45576 @default.
- NCIT_C45796 NCIT_R153 NCIT_C45680 @default.
- NCIT_C45796 NCIT_R153 NCIT_C97926 @default.
- NCIT_C45796 NCIT_R155 NCIT_C12219 @default.
- NCIT_C45796 NCIT_R155 NCIT_C13282 @default.
- NCIT_C45796 NCIT_R155 NCIT_C13377 @default.
- NCIT_C45796 NCIT_R155 NCIT_C13432 @default.
- NCIT_C45796 NCIT_R155 NCIT_C13446 @default.
- NCIT_C45796 NCIT_R155 NCIT_C14132 @default.
- NCIT_C45796 NCIT_R155 NCIT_C14135 @default.
- NCIT_C45796 NCIT_R155 NCIT_C32221 @default.
- NCIT_C45796 NCIT_R155 NCIT_C34070 @default.
- NCIT_C45796 NCIT_R37 NCIT_C16841 @default.
- NCIT_C45796 NCIT_R37 NCIT_C16848 @default.
- NCIT_C45796 NCIT_R37 NCIT_C17710 @default.
- NCIT_C45796 NCIT_R37 NCIT_C17828 @default.
- NCIT_C45796 NCIT_R37 NCIT_C19403 @default.
- NCIT_C45796 NCIT_R37 NCIT_C19536 @default.
- NCIT_C45796 NCIT_R37 NCIT_C19899 @default.
- NCIT_C45796 NCIT_R37 NCIT_C21198 @default.
- NCIT_C45796 NCIT_R37 NCIT_C26533 @default.
- NCIT_C45796 NCIT_R37 NCIT_C26633 @default.
- NCIT_C45796 NCIT_R37 NCIT_C28498 @default.
- NCIT_C45796 NCIT_R37 NCIT_C40468 @default.
- NCIT_C45796 NCIT_R38 NCIT_C26683 @default.
- NCIT_C45796 NCIT_R38 NCIT_C3367 @default.
- NCIT_C45796 NCIT_R38 NCIT_C3492 @default.
- NCIT_C45796 NCIT_R38 NCIT_C35553 @default.
- NCIT_C45796 NCIT_R38 NCIT_C36292 @default.
- NCIT_C45796 NCIT_R38 NCIT_C4389 @default.
- NCIT_C45796 NCIT_R38 NCIT_C7057 @default.
- NCIT_C45796 NCIT_R38 NCIT_C77140 @default.
- NCIT_C45796 NCIT_R40 NCIT_C12219 @default.
- NCIT_C45796 NCIT_R40 NCIT_C13282 @default.
- NCIT_C45796 NCIT_R40 NCIT_C13377 @default.
- NCIT_C45796 NCIT_R40 NCIT_C13432 @default.
- NCIT_C45796 NCIT_R40 NCIT_C13446 @default.
- NCIT_C45796 NCIT_R40 NCIT_C14132 @default.
- NCIT_C45796 NCIT_R40 NCIT_C14135 @default.
- NCIT_C45796 NCIT_R40 NCIT_C32221 @default.
- NCIT_C45796 NCIT_R40 NCIT_C34070 @default.
- NCIT_C45796 NCIT_R41 NCIT_C14182 @default.
- NCIT_C45796 NCIT_R41 NCIT_C14225 @default.
- NCIT_C45796 NCIT_R41 NCIT_C14234 @default.
- NCIT_C45796 NCIT_R41 NCIT_C14250 @default.
- NCIT_C45796 NCIT_R41 NCIT_C14262 @default.
- NCIT_C45796 NCIT_R41 NCIT_C14282 @default.
- NCIT_C45796 NCIT_R41 NCIT_C25796 @default.
- NCIT_C45796 NCIT_R41 NCIT_C79740 @default.
- NCIT_C45796 normalizedInformationContent "100" @default.
- NCIT_C45796 referenceCount "1" @default.
- NCIT_C45796 hasExactSynonym "TPMT*V3 Allele" @default.
- NCIT_C45796 hasExactSynonym "TPMT-V3" @default.
- NCIT_C45796 type Class @default.
- NCIT_C45796 isDefinedBy ncit.owl @default.
- NCIT_C45796 label "TPMT*V3 Allele" @default.
- NCIT_C45796 subClassOf B41b77550daf1fad34558ff2eddc06f72 @default.
- NCIT_C45796 subClassOf B557dad4822a3bc7ab7893270e729a147 @default.
- NCIT_C45796 subClassOf B7fe759851c9ab347ddd7fbc68f1d9b88 @default.
- NCIT_C45796 subClassOf Be5fb152ed78744e4da447b7f07e332a7 @default.
- NCIT_C45796 subClassOf NCIT_C16612 @default.
- NCIT_C45796 subClassOf NCIT_C21281 @default.
- NCIT_C45796 subClassOf NCIT_C21595 @default.
- NCIT_C45796 subClassOf NCIT_C25870 @default.
- NCIT_C45796 subClassOf NCIT_C26110 @default.
- NCIT_C45796 subClassOf NCIT_C45796 @default.