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- NCIT_C47390 IAO_0000115 "The hydrochloride salt of amiloride, a synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen." @default.
- NCIT_C47390 NCIT_A6 NCIT_C61633 @default.
- NCIT_C47390 NCIT_NHC0 "C47390" @default.
- NCIT_C47390 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47390 NCIT_P108 "Amiloride Hydrochloride" @default.
- NCIT_C47390 NCIT_P207 "C0026054" @default.
- NCIT_C47390 NCIT_P210 "17440-83-4" @default.
- NCIT_C47390 NCIT_P319 "FZJ37245UC" @default.
- NCIT_C47390 NCIT_P322 "FDA" @default.
- NCIT_C47390 NCIT_P350 "C6H8ClN7O.ClH.2H2O" @default.
- NCIT_C47390 NCIT_P366 "Amiloride_Hydrochloride" @default.
- NCIT_C47390 NCIT_P368 "CHEBI:2640" @default.
- NCIT_C47390 normalizedInformationContent "100" @default.
- NCIT_C47390 referenceCount "1" @default.
- NCIT_C47390 hasExactSynonym "AMILORIDE HYDROCHLORIDE" @default.
- NCIT_C47390 hasExactSynonym "Amiloride Hydrochloride" @default.
- NCIT_C47390 hasExactSynonym "CCRIS 5959" @default.
- NCIT_C47390 hasExactSynonym "KM87O" @default.
- NCIT_C47390 hasExactSynonym "Midamor" @default.
- NCIT_C47390 hasExactSynonym "N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide Monohydrochloride" @default.
- NCIT_C47390 hasExactSynonym "Pyrazinecarboxamide, N-Amidino-3,5-diamino-6-chloro-, Monohydrochloride" @default.
- NCIT_C47390 inSubset NCIT_C63923 @default.
- NCIT_C47390 type Class @default.
- NCIT_C47390 isDefinedBy ncit.owl @default.
- NCIT_C47390 label "Amiloride Hydrochloride" @default.
- NCIT_C47390 subClassOf NCIT_C186664 @default.
- NCIT_C47390 subClassOf NCIT_C1908 @default.
- NCIT_C47390 subClassOf NCIT_C1909 @default.
- NCIT_C47390 subClassOf NCIT_C274 @default.
- NCIT_C47390 subClassOf NCIT_C2842 @default.
- NCIT_C47390 subClassOf NCIT_C448 @default.
- NCIT_C47390 subClassOf NCIT_C47390 @default.
- NCIT_C47390 subClassOf NCIT_C49186 @default.
- NCIT_C47390 subClassOf NCIT_C582 @default.
- NCIT_C47390 subClassOf NCIT_C78275 @default.