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- NCIT_C47393 IAO_0000115 "A methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart." @default.
- NCIT_C47393 NCIT_NHC0 "C47393" @default.
- NCIT_C47393 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47393 NCIT_P107 "Aminophylline" @default.
- NCIT_C47393 NCIT_P108 "Aminophylline" @default.
- NCIT_C47393 NCIT_P175 "7919" @default.
- NCIT_C47393 NCIT_P207 "C0722625" @default.
- NCIT_C47393 NCIT_P210 "317-34-0" @default.
- NCIT_C47393 NCIT_P319 "27Y3KJK423" @default.
- NCIT_C47393 NCIT_P322 "CTRP" @default.
- NCIT_C47393 NCIT_P322 "FDA" @default.
- NCIT_C47393 NCIT_P329 "682624" @default.
- NCIT_C47393 NCIT_P330 "682624" @default.
- NCIT_C47393 NCIT_P350 "2C7H8N4O2.C2H8N2" @default.
- NCIT_C47393 NCIT_P366 "Aminophylline" @default.
- NCIT_C47393 NCIT_P399 "682624" @default.
- NCIT_C47393 normalizedInformationContent "100" @default.
- NCIT_C47393 referenceCount "1" @default.
- NCIT_C47393 hasExactSynonym "1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-Ethanediamine(2:1)" @default.
- NCIT_C47393 hasExactSynonym "AMINOPHYLLINE" @default.
- NCIT_C47393 hasExactSynonym "Aminophylline" @default.
- NCIT_C47393 hasExactSynonym "Ammophyllin" @default.
- NCIT_C47393 hasExactSynonym "Phyllocontin" @default.
- NCIT_C47393 hasExactSynonym "Theophyline Ethylenediamine" @default.
- NCIT_C47393 hasExactSynonym "Truphylline" @default.
- NCIT_C47393 inSubset NCIT_C116977 @default.
- NCIT_C47393 inSubset NCIT_C116978 @default.
- NCIT_C47393 inSubset NCIT_C176424 @default.
- NCIT_C47393 inSubset NCIT_C63923 @default.
- NCIT_C47393 type Class @default.
- NCIT_C47393 isDefinedBy ncit.owl @default.
- NCIT_C47393 label "Aminophylline" @default.
- NCIT_C47393 subClassOf NCIT_C1908 @default.
- NCIT_C47393 subClassOf NCIT_C1909 @default.
- NCIT_C47393 subClassOf NCIT_C29712 @default.
- NCIT_C47393 subClassOf NCIT_C319 @default.
- NCIT_C47393 subClassOf NCIT_C471 @default.
- NCIT_C47393 subClassOf NCIT_C47393 @default.
- NCIT_C47393 subClassOf NCIT_C744 @default.
- NCIT_C47393 subClassOf NCIT_C78273 @default.