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- NCIT_C47417 IAO_0000115 "A sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension." @default.
- NCIT_C47417 NCIT_A7 NCIT_C105930 @default.
- NCIT_C47417 NCIT_A7 NCIT_C71453 @default.
- NCIT_C47417 NCIT_NHC0 "C47417" @default.
- NCIT_C47417 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47417 NCIT_P107 "Bosentan" @default.
- NCIT_C47417 NCIT_P108 "Bosentan" @default.
- NCIT_C47417 NCIT_P207 "C0252643" @default.
- NCIT_C47417 NCIT_P210 "157212-55-0" @default.
- NCIT_C47417 NCIT_P319 "Q326023R30" @default.
- NCIT_C47417 NCIT_P322 "CTRP" @default.
- NCIT_C47417 NCIT_P322 "FDA" @default.
- NCIT_C47417 NCIT_P350 "C27H29N5O6S.H2O" @default.
- NCIT_C47417 NCIT_P366 "Bosentan" @default.
- NCIT_C47417 NCIT_P368 "CHEBI:31300" @default.
- NCIT_C47417 NCIT_P399 "810796" @default.
- NCIT_C47417 normalizedInformationContent "100" @default.
- NCIT_C47417 referenceCount "1" @default.
- NCIT_C47417 hasExactSynonym "4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide" @default.
- NCIT_C47417 hasExactSynonym "BOSENTAN" @default.
- NCIT_C47417 hasExactSynonym "Bosentan Monohydrate" @default.
- NCIT_C47417 hasExactSynonym "Bosentan" @default.
- NCIT_C47417 hasExactSynonym "Ro 47-0203" @default.
- NCIT_C47417 hasExactSynonym "Tracleer" @default.
- NCIT_C47417 inSubset NCIT_C116977 @default.
- NCIT_C47417 inSubset NCIT_C116978 @default.
- NCIT_C47417 inSubset NCIT_C176424 @default.
- NCIT_C47417 inSubset NCIT_C63923 @default.
- NCIT_C47417 type Class @default.
- NCIT_C47417 isDefinedBy ncit.owl @default.
- NCIT_C47417 label "Bosentan" @default.
- NCIT_C47417 subClassOf NCIT_C1908 @default.
- NCIT_C47417 subClassOf NCIT_C1909 @default.
- NCIT_C47417 subClassOf NCIT_C28313 @default.
- NCIT_C47417 subClassOf NCIT_C47417 @default.