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- NCIT_C47424 IAO_0000115 "The hydrochloride salt form of buprenorphine, a synthetic phenanthrene with narcotic analgesic activity. Buprenorphine hydrochloride is a partial agonist at the mu-opioid receptor and an antagonist at the kapa-opioid receptor in the central nervous system. However, under the conditions of recommended use it behaves as a classic mu-opioid agonist, mimicking the actions of endogenous peptides at CNS opioid receptors. The agonist action results in a raised pain threshold and increased tolerance to pain. However, it also causes sedation, physical dependence, and respiratory depressant effects and decreases heart rate and blood pressure." @default.
- NCIT_C47424 NCIT_A6 NCIT_C61656 @default.
- NCIT_C47424 NCIT_NHC0 "C47424" @default.
- NCIT_C47424 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47424 NCIT_P108 "Buprenorphine Hydrochloride" @default.
- NCIT_C47424 NCIT_P207 "C0006404" @default.
- NCIT_C47424 NCIT_P210 "53152-21-9" @default.
- NCIT_C47424 NCIT_P319 "56W8MW3EN1" @default.
- NCIT_C47424 NCIT_P322 "FDA" @default.
- NCIT_C47424 NCIT_P350 "C29H41NO4.HCl" @default.
- NCIT_C47424 NCIT_P366 "Buprenorphine_Hydrochloride" @default.
- NCIT_C47424 NCIT_P368 "CHEBI:652822" @default.
- NCIT_C47424 normalizedInformationContent "100" @default.
- NCIT_C47424 referenceCount "1" @default.
- NCIT_C47424 hasExactSynonym "(5alpha,7alpha(S))-alpha-tert-Butyl-17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol Hydrochloride" @default.
- NCIT_C47424 hasExactSynonym "BUPRENORPHINE HYDROCHLORIDE" @default.
- NCIT_C47424 hasExactSynonym "Buprenex" @default.
- NCIT_C47424 hasExactSynonym "Buprenorphine Hydrochloride" @default.
- NCIT_C47424 hasExactSynonym "NIH 8805" @default.
- NCIT_C47424 hasExactSynonym "RX 6029-M HCl" @default.
- NCIT_C47424 hasExactSynonym "Subutex" @default.
- NCIT_C47424 inSubset NCIT_C63923 @default.
- NCIT_C47424 type Class @default.
- NCIT_C47424 isDefinedBy ncit.owl @default.
- NCIT_C47424 label "Buprenorphine Hydrochloride" @default.
- NCIT_C47424 subClassOf NCIT_C1506 @default.
- NCIT_C47424 subClassOf NCIT_C1908 @default.
- NCIT_C47424 subClassOf NCIT_C1909 @default.
- NCIT_C47424 subClassOf NCIT_C1913 @default.
- NCIT_C47424 subClassOf NCIT_C1916 @default.
- NCIT_C47424 subClassOf NCIT_C221 @default.
- NCIT_C47424 subClassOf NCIT_C47424 @default.
- NCIT_C47424 subClassOf NCIT_C67413 @default.
- NCIT_C47424 subClassOf NCIT_C718 @default.
- NCIT_C47424 subClassOf NCIT_C78272 @default.