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- NCIT_C47434 IAO_0000115 "A semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intestinal esterases during absorption to the microbiologically active cefditoren, an active aminothiazolyl cephalosporin. Cefditoren inactivates penicillin binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting bacterial cell wall synthesis. Another consequence of beta-lactam exposure results in the loss of lipoteichoic acids from the cell wall. Lipoteichoic acids inhibit murein hydrolase activity and their absence from the cell wall triggers uncontrolled autolytic activity rendering bacterial cells susceptible to osmotic shock. This results in a reduction of cell wall stability and causes cell lysis." @default.
- NCIT_C47434 NCIT_NHC0 "C47434" @default.
- NCIT_C47434 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47434 NCIT_P108 "Cefditoren Pivoxil" @default.
- NCIT_C47434 NCIT_P207 "C0245519" @default.
- NCIT_C47434 NCIT_P210 "117467-28-4" @default.
- NCIT_C47434 NCIT_P319 "78THA212DH" @default.
- NCIT_C47434 NCIT_P322 "FDA" @default.
- NCIT_C47434 NCIT_P350 "C25H28N6O7S3" @default.
- NCIT_C47434 NCIT_P366 "Cefditoren_Pivoxil" @default.
- NCIT_C47434 NCIT_P368 "CHEBI:560555" @default.
- NCIT_C47434 normalizedInformationContent "100" @default.
- NCIT_C47434 referenceCount "1" @default.
- NCIT_C47434 hasExactSynonym "5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((1Z)-2-(4-methyl-5-thiazolyl)ethenyl)-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl Ester,(6R,7R)-" @default.
- NCIT_C47434 hasExactSynonym "CCRIS 7768" @default.
- NCIT_C47434 hasExactSynonym "CEFDITOREN PIVOXIL" @default.
- NCIT_C47434 hasExactSynonym "Cefditoren Pivoxil" @default.
- NCIT_C47434 hasExactSynonym "ME 1207" @default.
- NCIT_C47434 hasExactSynonym "Spectracef" @default.
- NCIT_C47434 inSubset NCIT_C63923 @default.
- NCIT_C47434 type Class @default.
- NCIT_C47434 isDefinedBy ncit.owl @default.
- NCIT_C47434 label "Cefditoren Pivoxil" @default.
- NCIT_C47434 subClassOf NCIT_C1908 @default.
- NCIT_C47434 subClassOf NCIT_C1909 @default.
- NCIT_C47434 subClassOf NCIT_C254 @default.
- NCIT_C47434 subClassOf NCIT_C258 @default.
- NCIT_C47434 subClassOf NCIT_C260 @default.
- NCIT_C47434 subClassOf NCIT_C357 @default.
- NCIT_C47434 subClassOf NCIT_C47434 @default.