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- NCIT_C47441 IAO_0000115 "A beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephradine binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.
- NCIT_C47441 NCIT_NHC0 "C47441" @default.
- NCIT_C47441 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47441 NCIT_P108 "Cephradine" @default.
- NCIT_C47441 NCIT_P207 "C0007738" @default.
- NCIT_C47441 NCIT_P210 "31828-50-9" @default.
- NCIT_C47441 NCIT_P319 "F1BC02I72W" @default.
- NCIT_C47441 NCIT_P322 "FDA" @default.
- NCIT_C47441 NCIT_P366 "Cephradine" @default.
- NCIT_C47441 normalizedInformationContent "100" @default.
- NCIT_C47441 referenceCount "1" @default.
- NCIT_C47441 hasExactSynonym "(6R,7R)-7-((R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid" @default.
- NCIT_C47441 hasExactSynonym "7-(D-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-caboxylic Acid" @default.
- NCIT_C47441 hasExactSynonym "Anspor" @default.
- NCIT_C47441 hasExactSynonym "CEPHRADINE" @default.
- NCIT_C47441 hasExactSynonym "Cefradine" @default.
- NCIT_C47441 hasExactSynonym "Cephradine" @default.
- NCIT_C47441 hasExactSynonym "SK&F D-39304" @default.
- NCIT_C47441 hasExactSynonym "SQ 11436" @default.
- NCIT_C47441 hasExactSynonym "Velosef" @default.
- NCIT_C47441 inSubset NCIT_C63923 @default.
- NCIT_C47441 type Class @default.
- NCIT_C47441 isDefinedBy ncit.owl @default.
- NCIT_C47441 label "Cephradine" @default.
- NCIT_C47441 subClassOf NCIT_C1908 @default.
- NCIT_C47441 subClassOf NCIT_C1909 @default.
- NCIT_C47441 subClassOf NCIT_C254 @default.
- NCIT_C47441 subClassOf NCIT_C258 @default.
- NCIT_C47441 subClassOf NCIT_C260 @default.
- NCIT_C47441 subClassOf NCIT_C357 @default.
- NCIT_C47441 subClassOf NCIT_C47441 @default.