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- NCIT_C47450 IAO_0000115 "The orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth." @default.
- NCIT_C47450 NCIT_A32 NCIT_C1909 @default.
- NCIT_C47450 NCIT_A6 NCIT_C74100 @default.
- NCIT_C47450 NCIT_A7 NCIT_C41027 @default.
- NCIT_C47450 NCIT_NHC0 "C47450" @default.
- NCIT_C47450 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47450 NCIT_P107 "Cinacalcet Hydrochloride" @default.
- NCIT_C47450 NCIT_P108 "Cinacalcet Hydrochloride" @default.
- NCIT_C47450 NCIT_P207 "C1260199" @default.
- NCIT_C47450 NCIT_P210 "364782-34-3" @default.
- NCIT_C47450 NCIT_P319 "1K860WSG25" @default.
- NCIT_C47450 NCIT_P322 "CTRP" @default.
- NCIT_C47450 NCIT_P322 "FDA" @default.
- NCIT_C47450 NCIT_P322 "GDC" @default.
- NCIT_C47450 NCIT_P329 "662071" @default.
- NCIT_C47450 NCIT_P330 "662071" @default.
- NCIT_C47450 NCIT_P350 "C22H22F3N.HCl" @default.
- NCIT_C47450 NCIT_P366 "Cinacalcet_Hydrochloride" @default.
- NCIT_C47450 NCIT_P368 "CHEBI:48391" @default.
- NCIT_C47450 NCIT_P375 "Cinacalcet Hydrochloride" @default.
- NCIT_C47450 NCIT_P399 "662071" @default.
- NCIT_C47450 normalizedInformationContent "100" @default.
- NCIT_C47450 referenceCount "1" @default.
- NCIT_C47450 hasExactSynonym "1-Naphthalenemethanamine, a-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-,(aR)-, Hydrochloride" @default.
- NCIT_C47450 hasExactSynonym "CINACALCET HYDROCHLORIDE" @default.
- NCIT_C47450 hasExactSynonym "Cinacalcet Hydrochloride" @default.
- NCIT_C47450 hasExactSynonym "Mimpara" @default.
- NCIT_C47450 hasExactSynonym "Sensipar" @default.
- NCIT_C47450 inSubset NCIT_C116977 @default.
- NCIT_C47450 inSubset NCIT_C116978 @default.
- NCIT_C47450 inSubset NCIT_C128784 @default.
- NCIT_C47450 inSubset NCIT_C157711 @default.
- NCIT_C47450 inSubset NCIT_C157712 @default.
- NCIT_C47450 inSubset NCIT_C176424 @default.
- NCIT_C47450 inSubset NCIT_C177537 @default.
- NCIT_C47450 inSubset NCIT_C63923 @default.
- NCIT_C47450 type Class @default.
- NCIT_C47450 isDefinedBy ncit.owl @default.
- NCIT_C47450 label "Cinacalcet Hydrochloride" @default.
- NCIT_C47450 subClassOf NCIT_C1908 @default.
- NCIT_C47450 subClassOf NCIT_C1909 @default.
- NCIT_C47450 subClassOf NCIT_C2136 @default.
- NCIT_C47450 subClassOf NCIT_C47450 @default.
- NCIT_C47450 subClassOf NCIT_C78275 @default.