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- NCIT_C47470 IAO_0000115 "A semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum antibiotic activity against Gram-positive bacteria. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to calcium-dependant potassium efflux; the loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis, resulting in bacterial cell death. This agent does not penetrate the outer membrane of gram-negative bacteria." @default.
- NCIT_C47470 NCIT_NHC0 "C47470" @default.
- NCIT_C47470 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47470 NCIT_P107 "Daptomycin" @default.
- NCIT_C47470 NCIT_P108 "Daptomycin" @default.
- NCIT_C47470 NCIT_P207 "C0057144" @default.
- NCIT_C47470 NCIT_P210 "103060-53-3" @default.
- NCIT_C47470 NCIT_P319 "NWQ5N31VKK" @default.
- NCIT_C47470 NCIT_P322 "CTRP" @default.
- NCIT_C47470 NCIT_P322 "FDA" @default.
- NCIT_C47470 NCIT_P325 "A drug used to treat certain bacterial skin and bloodstream infections in adults. Cubicin is also being studied in the treatment of fever and neutropenia (an abnormal decrease in the number of neutrophils, a type of white blood cell) in patients with cancer. It is a type of antibiotic." @default.
- NCIT_C47470 NCIT_P329 "469015" @default.
- NCIT_C47470 NCIT_P330 "469015" @default.
- NCIT_C47470 NCIT_P350 "C72H101N17O26" @default.
- NCIT_C47470 NCIT_P366 "Daptomycin" @default.
- NCIT_C47470 NCIT_P368 "CHEBI:600103" @default.
- NCIT_C47470 NCIT_P399 "469015" @default.
- NCIT_C47470 normalizedInformationContent "100" @default.
- NCIT_C47470 referenceCount "1" @default.
- NCIT_C47470 hasExactSynonym "Cubicin" @default.
- NCIT_C47470 hasExactSynonym "DAPTOMYCIN" @default.
- NCIT_C47470 hasExactSynonym "Daptomycin" @default.
- NCIT_C47470 hasExactSynonym "LY146032" @default.
- NCIT_C47470 hasExactSynonym "N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone" @default.
- NCIT_C47470 hasExactSynonym "daptomycin" @default.
- NCIT_C47470 inSubset NCIT_C116977 @default.
- NCIT_C47470 inSubset NCIT_C116978 @default.
- NCIT_C47470 inSubset NCIT_C176424 @default.
- NCIT_C47470 inSubset NCIT_C63923 @default.
- NCIT_C47470 type Class @default.
- NCIT_C47470 isDefinedBy ncit.owl @default.
- NCIT_C47470 label "Daptomycin" @default.
- NCIT_C47470 subClassOf NCIT_C1908 @default.
- NCIT_C47470 subClassOf NCIT_C1909 @default.
- NCIT_C47470 subClassOf NCIT_C2363 @default.
- NCIT_C47470 subClassOf NCIT_C254 @default.
- NCIT_C47470 subClassOf NCIT_C258 @default.
- NCIT_C47470 subClassOf NCIT_C47470 @default.
- NCIT_C47470 subClassOf NCIT_C784 @default.