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- NCIT_C47476 IAO_0000115 "A synthetic progestogen structurally related to levonorgestrel, with progesterone hormone receptor agonistic activity, used as a contraceptive and hormone replacement agent. Upon administration, desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA causing either gene transcription or gene repression. This eventually leads to an inhibition of gonadotropin releasing hormone (GnRH) secretion from the hypothalamus and a subsequent inhibition of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. This prevents ovulation and alters the cervical mucus." @default.
- NCIT_C47476 NCIT_NHC0 "C47476" @default.
- NCIT_C47476 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47476 NCIT_P108 "Desogestrel" @default.
- NCIT_C47476 NCIT_P207 "C0057558" @default.
- NCIT_C47476 NCIT_P210 "54024-22-5" @default.
- NCIT_C47476 NCIT_P319 "81K9V7M3A3" @default.
- NCIT_C47476 NCIT_P322 "FDA" @default.
- NCIT_C47476 NCIT_P329 "743774" @default.
- NCIT_C47476 NCIT_P330 "743774" @default.
- NCIT_C47476 NCIT_P350 "C22H30O" @default.
- NCIT_C47476 NCIT_P366 "Desogestrel" @default.
- NCIT_C47476 NCIT_P368 "CHEBI:4453" @default.
- NCIT_C47476 NCIT_P399 "743774" @default.
- NCIT_C47476 normalizedInformationContent "100" @default.
- NCIT_C47476 referenceCount "1" @default.
- NCIT_C47476 hasExactSynonym "13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol" @default.
- NCIT_C47476 hasExactSynonym "Cerazette" @default.
- NCIT_C47476 hasExactSynonym "DESOGESTREL" @default.
- NCIT_C47476 hasExactSynonym "Desogestrel" @default.
- NCIT_C47476 inSubset NCIT_C176424 @default.
- NCIT_C47476 inSubset NCIT_C63923 @default.
- NCIT_C47476 type Class @default.
- NCIT_C47476 isDefinedBy ncit.owl @default.
- NCIT_C47476 label "Desogestrel" @default.
- NCIT_C47476 subClassOf NCIT_C147908 @default.
- NCIT_C47476 subClassOf NCIT_C1636 @default.
- NCIT_C47476 subClassOf NCIT_C1908 @default.
- NCIT_C47476 subClassOf NCIT_C1909 @default.
- NCIT_C47476 subClassOf NCIT_C47476 @default.
- NCIT_C47476 subClassOf NCIT_C548 @default.
- NCIT_C47476 subClassOf NCIT_C776 @default.