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- NCIT_C47479 IAO_0000115 "An imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative properties. Dexmedetomidine selectively binds to presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibit sympathetic activity, thereby leading to sedation and anxiolysis. The analgesic effect of this agent is mediated by binding to alpha-2 adrenoceptors in the spinal cord." @default.
- NCIT_C47479 NCIT_A5 NCIT_C72738 @default.
- NCIT_C47479 NCIT_NHC0 "C47479" @default.
- NCIT_C47479 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47479 NCIT_P108 "Dexmedetomidine" @default.
- NCIT_C47479 NCIT_P207 "C0113293" @default.
- NCIT_C47479 NCIT_P210 "113775-47-6" @default.
- NCIT_C47479 NCIT_P319 "67VB76HONO" @default.
- NCIT_C47479 NCIT_P322 "FDA" @default.
- NCIT_C47479 NCIT_P350 "C13H16N2" @default.
- NCIT_C47479 NCIT_P366 "Dexmedetomidine" @default.
- NCIT_C47479 NCIT_P368 "CHEBI:4466" @default.
- NCIT_C47479 normalizedInformationContent "100" @default.
- NCIT_C47479 referenceCount "1" @default.
- NCIT_C47479 hasExactSynonym "(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole" @default.
- NCIT_C47479 hasExactSynonym "DEXMEDETOMIDINE" @default.
- NCIT_C47479 hasExactSynonym "Dexmedetomidine" @default.
- NCIT_C47479 inSubset NCIT_C173381 @default.
- NCIT_C47479 inSubset NCIT_C173383 @default.
- NCIT_C47479 inSubset NCIT_C63923 @default.
- NCIT_C47479 type Class @default.
- NCIT_C47479 isDefinedBy ncit.owl @default.
- NCIT_C47479 label "Dexmedetomidine" @default.
- NCIT_C47479 subClassOf NCIT_C1908 @default.
- NCIT_C47479 subClassOf NCIT_C1909 @default.
- NCIT_C47479 subClassOf NCIT_C29709 @default.
- NCIT_C47479 subClassOf NCIT_C29747 @default.
- NCIT_C47479 subClassOf NCIT_C47479 @default.
- NCIT_C47479 subClassOf NCIT_C78272 @default.
- NCIT_C47479 subClassOf NCIT_C87053 @default.