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- NCIT_C47503 IAO_0000115 "A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver." @default.
- NCIT_C47503 NCIT_NHC0 "C47503" @default.
- NCIT_C47503 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47503 NCIT_P107 "Dutasteride" @default.
- NCIT_C47503 NCIT_P108 "Dutasteride" @default.
- NCIT_C47503 NCIT_P207 "C0754659" @default.
- NCIT_C47503 NCIT_P210 "164656-23-9" @default.
- NCIT_C47503 NCIT_P319 "O0J6XJN02I" @default.
- NCIT_C47503 NCIT_P322 "CTRP" @default.
- NCIT_C47503 NCIT_P322 "FDA" @default.
- NCIT_C47503 NCIT_P325 "A drug used to treat symptoms of an enlarged prostate gland. It is being studied in the treatment of male hair loss and prostate cancer. Avodart blocks enzymes the body needs to make male sex hormones. It is a type of 5-alpha reductase inhibitor." @default.
- NCIT_C47503 NCIT_P329 "479183" @default.
- NCIT_C47503 NCIT_P330 "479183" @default.
- NCIT_C47503 NCIT_P350 "C27H30F6N2O2" @default.
- NCIT_C47503 NCIT_P366 "Dutasteride" @default.
- NCIT_C47503 NCIT_P368 "CHEBI:521033" @default.
- NCIT_C47503 NCIT_P399 "479183" @default.
- NCIT_C47503 normalizedInformationContent "100" @default.
- NCIT_C47503 referenceCount "1" @default.
- NCIT_C47503 hasExactSynonym "Avodart" @default.
- NCIT_C47503 hasExactSynonym "Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide" @default.
- NCIT_C47503 hasExactSynonym "DUTASTERIDE" @default.
- NCIT_C47503 hasExactSynonym "Dutasteride" @default.
- NCIT_C47503 hasExactSynonym "GG 745" @default.
- NCIT_C47503 hasExactSynonym "GG745" @default.
- NCIT_C47503 hasExactSynonym "alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide" @default.
- NCIT_C47503 hasExactSynonym "dutasteride" @default.
- NCIT_C47503 inSubset NCIT_C116977 @default.
- NCIT_C47503 inSubset NCIT_C116978 @default.
- NCIT_C47503 inSubset NCIT_C128784 @default.
- NCIT_C47503 inSubset NCIT_C173381 @default.
- NCIT_C47503 inSubset NCIT_C173383 @default.
- NCIT_C47503 inSubset NCIT_C176424 @default.
- NCIT_C47503 inSubset NCIT_C63923 @default.
- NCIT_C47503 type Class @default.
- NCIT_C47503 isDefinedBy ncit.owl @default.
- NCIT_C47503 label "Dutasteride" @default.
- NCIT_C47503 subClassOf NCIT_C147908 @default.
- NCIT_C47503 subClassOf NCIT_C1892 @default.
- NCIT_C47503 subClassOf NCIT_C1908 @default.
- NCIT_C47503 subClassOf NCIT_C1909 @default.
- NCIT_C47503 subClassOf NCIT_C2319 @default.
- NCIT_C47503 subClassOf NCIT_C242 @default.
- NCIT_C47503 subClassOf NCIT_C471 @default.
- NCIT_C47503 subClassOf NCIT_C47503 @default.
- NCIT_C47503 subClassOf NCIT_C547 @default.