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- NCIT_C47519 IAO_0000115 "The hydrochloride salt form of esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation." @default.
- NCIT_C47519 NCIT_A6 NCIT_C72617 @default.
- NCIT_C47519 NCIT_NHC0 "C47519" @default.
- NCIT_C47519 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47519 NCIT_P108 "Esmolol Hydrochloride" @default.
- NCIT_C47519 NCIT_P207 "C0700606" @default.
- NCIT_C47519 NCIT_P210 "81161-17-3" @default.
- NCIT_C47519 NCIT_P319 "V05260LC8D" @default.
- NCIT_C47519 NCIT_P322 "FDA" @default.
- NCIT_C47519 NCIT_P350 "C16H25NO4.HCl" @default.
- NCIT_C47519 NCIT_P366 "Esmolol_Hydrochloride" @default.
- NCIT_C47519 NCIT_P368 "CHEBI:4857" @default.
- NCIT_C47519 normalizedInformationContent "100" @default.
- NCIT_C47519 referenceCount "1" @default.
- NCIT_C47519 hasExactSynonym "(+-)-Methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate Hydrochloride" @default.
- NCIT_C47519 hasExactSynonym "4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoic Acid Methyl Ester HCl" @default.
- NCIT_C47519 hasExactSynonym "ASL 8052" @default.
- NCIT_C47519 hasExactSynonym "Brevibloc" @default.
- NCIT_C47519 hasExactSynonym "ESMOLOL HYDROCHLORIDE" @default.
- NCIT_C47519 hasExactSynonym "Esmolol Hydrochloride" @default.
- NCIT_C47519 inSubset NCIT_C63923 @default.
- NCIT_C47519 type Class @default.
- NCIT_C47519 isDefinedBy ncit.owl @default.
- NCIT_C47519 label "Esmolol Hydrochloride" @default.
- NCIT_C47519 subClassOf NCIT_C1908 @default.
- NCIT_C47519 subClassOf NCIT_C1909 @default.
- NCIT_C47519 subClassOf NCIT_C29576 @default.
- NCIT_C47519 subClassOf NCIT_C29747 @default.
- NCIT_C47519 subClassOf NCIT_C47519 @default.
- NCIT_C47519 subClassOf NCIT_C72900 @default.
- NCIT_C47519 subClassOf NCIT_C78272 @default.