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- NCIT_C47524 IAO_0000115 "A hydantoin anticonvulsant with anti-epileptic activity. The mechanism of action is not completely known, but is thought to be fairly similar to phenytoin. Ethotoin influences synaptic transmission by altering sodium and calcium ion influx across neuronal membranes in the repolarization, depolarization, and membrane stability phase and interferes with the calcium uptake in presynaptic terminals. This inhibits neuronal firing and results in the stabilization of neuronal membranes, thereby preventing the spread of seizure activity at the motor cortex." @default.
- NCIT_C47524 NCIT_NHC0 "C47524" @default.
- NCIT_C47524 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47524 NCIT_P108 "Ethotoin" @default.
- NCIT_C47524 NCIT_P207 "C0015046" @default.
- NCIT_C47524 NCIT_P210 "86-35-1" @default.
- NCIT_C47524 NCIT_P319 "46QG38NC4U" @default.
- NCIT_C47524 NCIT_P322 "FDA" @default.
- NCIT_C47524 NCIT_P350 "C11H12N2O2" @default.
- NCIT_C47524 NCIT_P366 "Ethotoin" @default.
- NCIT_C47524 NCIT_P368 "CHEBI:4888" @default.
- NCIT_C47524 normalizedInformationContent "100" @default.
- NCIT_C47524 referenceCount "1" @default.
- NCIT_C47524 hasExactSynonym "3-ethyl-5-phenyl-2,4-imidazolidinedione" @default.
- NCIT_C47524 hasExactSynonym "ETHOTOIN" @default.
- NCIT_C47524 hasExactSynonym "Ethotoin" @default.
- NCIT_C47524 hasExactSynonym "Hydantoin, 3-ethyl-5-phenyl-" @default.
- NCIT_C47524 hasExactSynonym "Peganone" @default.
- NCIT_C47524 inSubset NCIT_C63923 @default.
- NCIT_C47524 type Class @default.
- NCIT_C47524 isDefinedBy ncit.owl @default.
- NCIT_C47524 label "Ethotoin" @default.
- NCIT_C47524 subClassOf NCIT_C1908 @default.
- NCIT_C47524 subClassOf NCIT_C1909 @default.
- NCIT_C47524 subClassOf NCIT_C264 @default.
- NCIT_C47524 subClassOf NCIT_C47524 @default.
- NCIT_C47524 subClassOf NCIT_C78272 @default.