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- NCIT_C47542 IAO_0000115 "The sodium salt of fosinopril, a phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Fosinopril sodium is an ester prodrug that is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase of serum potassium. (NCI05)" @default.
- NCIT_C47542 NCIT_A6 NCIT_C65761 @default.
- NCIT_C47542 NCIT_NHC0 "C47542" @default.
- NCIT_C47542 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47542 NCIT_P108 "Fosinopril Sodium" @default.
- NCIT_C47542 NCIT_P207 "C0733440" @default.
- NCIT_C47542 NCIT_P210 "88889-14-9" @default.
- NCIT_C47542 NCIT_P319 "NW2RTH6T2N" @default.
- NCIT_C47542 NCIT_P322 "FDA" @default.
- NCIT_C47542 NCIT_P350 "C30H45NO7P.Na" @default.
- NCIT_C47542 NCIT_P366 "Fosinopril_Sodium" @default.
- NCIT_C47542 NCIT_P368 "CHEBI:5164" @default.
- NCIT_C47542 normalizedInformationContent "100" @default.
- NCIT_C47542 referenceCount "1" @default.
- NCIT_C47542 hasExactSynonym "Eliten" @default.
- NCIT_C47542 hasExactSynonym "FOSINOPRIL SODIUM" @default.
- NCIT_C47542 hasExactSynonym "Fosinopril Sodium" @default.
- NCIT_C47542 hasExactSynonym "L-proline, 4-Cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy) propoxyl](4-phenylbutyl) phosphinyl]acetyl]-,Sodium Salt, trans-" @default.
- NCIT_C47542 hasExactSynonym "Monopril" @default.
- NCIT_C47542 hasExactSynonym "Newace" @default.
- NCIT_C47542 inSubset NCIT_C63923 @default.
- NCIT_C47542 type Class @default.
- NCIT_C47542 isDefinedBy ncit.owl @default.
- NCIT_C47542 label "Fosinopril Sodium" @default.
- NCIT_C47542 subClassOf NCIT_C1908 @default.
- NCIT_C47542 subClassOf NCIT_C1909 @default.
- NCIT_C47542 subClassOf NCIT_C247 @default.
- NCIT_C47542 subClassOf NCIT_C270 @default.
- NCIT_C47542 subClassOf NCIT_C471 @default.
- NCIT_C47542 subClassOf NCIT_C47542 @default.
- NCIT_C47542 subClassOf NCIT_C78274 @default.
- NCIT_C47542 subClassOf NCIT_C783 @default.