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- NCIT_C47543 IAO_0000115 "The sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration. Phenytoin exerts its effect most likely through an enhancement of sodium efflux from neurons in the motor cortex. This leads to a suppression of excessive neuronal firing and spread of seizure activity. Other physiologic effects from actions of phenytoin include modulation of the voltage-dependent calcium channels of neurons, inhibition of calcium flux across neuronal membranes and enhancement of sodium-potassium ATPase activity of neurons and glial cells. (NCI05)" @default.
- NCIT_C47543 NCIT_A6 NCIT_C65766 @default.
- NCIT_C47543 NCIT_NHC0 "C47543" @default.
- NCIT_C47543 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47543 NCIT_P108 "Fosphenytoin Sodium" @default.
- NCIT_C47543 NCIT_P207 "C0284906" @default.
- NCIT_C47543 NCIT_P210 "92134-98-0" @default.
- NCIT_C47543 NCIT_P319 "7VLR55452Z" @default.
- NCIT_C47543 NCIT_P322 "FDA" @default.
- NCIT_C47543 NCIT_P329 "797055" @default.
- NCIT_C47543 NCIT_P330 "797055" @default.
- NCIT_C47543 NCIT_P350 "C16H13N2O6P.2Na" @default.
- NCIT_C47543 NCIT_P366 "Fosphenytoin_Sodium" @default.
- NCIT_C47543 NCIT_P399 "797055" @default.
- NCIT_C47543 normalizedInformationContent "100" @default.
- NCIT_C47543 referenceCount "1" @default.
- NCIT_C47543 hasExactSynonym "2,4-Imidazolidinedione, 5,5-diphenyl-3-((phosphonooxy)methyl)-, Disodium Salt" @default.
- NCIT_C47543 hasExactSynonym "Cerebyx" @default.
- NCIT_C47543 hasExactSynonym "FOSPHENYTOIN SODIUM" @default.
- NCIT_C47543 hasExactSynonym "Fosphenytoin Sodium" @default.
- NCIT_C47543 inSubset NCIT_C176424 @default.
- NCIT_C47543 inSubset NCIT_C63923 @default.
- NCIT_C47543 type Class @default.
- NCIT_C47543 isDefinedBy ncit.owl @default.
- NCIT_C47543 label "Fosphenytoin Sodium" @default.
- NCIT_C47543 subClassOf NCIT_C1908 @default.
- NCIT_C47543 subClassOf NCIT_C1909 @default.
- NCIT_C47543 subClassOf NCIT_C264 @default.
- NCIT_C47543 subClassOf NCIT_C47543 @default.
- NCIT_C47543 subClassOf NCIT_C78272 @default.