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- NCIT_C47555 IAO_0000115 "A semi-synthetic penicillin compound with bactericidal properties. Hetacillin is a prodrug that is converted to ampicillin via esterases. Ampicillin binds to inactivated penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs, including transpeptidases, carboxypeptidases, and endopeptidases, participate in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This results in the weakening of the bacterial cell wall and eventually causes cell lysis. (NCI05)" @default.
- NCIT_C47555 NCIT_A5 NCIT_C65845 @default.
- NCIT_C47555 NCIT_NHC0 "C47555" @default.
- NCIT_C47555 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47555 NCIT_P108 "Hetacillin" @default.
- NCIT_C47555 NCIT_P207 "C0062587" @default.
- NCIT_C47555 NCIT_P210 "3511-16-8" @default.
- NCIT_C47555 NCIT_P319 "TN4JSC48CV" @default.
- NCIT_C47555 NCIT_P322 "FDA" @default.
- NCIT_C47555 NCIT_P350 "C19H23N3O4S" @default.
- NCIT_C47555 NCIT_P366 "Hetacillin" @default.
- NCIT_C47555 NCIT_P368 "CHEBI:5683" @default.
- NCIT_C47555 normalizedInformationContent "100" @default.
- NCIT_C47555 referenceCount "1" @default.
- NCIT_C47555 hasExactSynonym "6-(2,2-Dimethyl-5-oxo-4-phenyl-1-imidazolidinyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid" @default.
- NCIT_C47555 hasExactSynonym "HETACILLIN" @default.
- NCIT_C47555 hasExactSynonym "Hetacillin" @default.
- NCIT_C47555 hasExactSynonym "N,N'-Isopropylidene-A-amino-benzyl Penicillin" @default.
- NCIT_C47555 hasExactSynonym "Phenazacillin" @default.
- NCIT_C47555 hasExactSynonym "Versapen" @default.
- NCIT_C47555 inSubset NCIT_C63923 @default.
- NCIT_C47555 type Class @default.
- NCIT_C47555 isDefinedBy ncit.owl @default.
- NCIT_C47555 label "Hetacillin" @default.
- NCIT_C47555 subClassOf NCIT_C1500 @default.
- NCIT_C47555 subClassOf NCIT_C1908 @default.
- NCIT_C47555 subClassOf NCIT_C1909 @default.
- NCIT_C47555 subClassOf NCIT_C254 @default.
- NCIT_C47555 subClassOf NCIT_C258 @default.
- NCIT_C47555 subClassOf NCIT_C260 @default.
- NCIT_C47555 subClassOf NCIT_C47555 @default.