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- NCIT_C47573 IAO_0000115 "A hydralazine and monoamine oxidase (MAO) inhibitor with antidepressant activity. Isocarboxazid blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine (5-HT) at central aminergic receptors. These neurotransmitters are involved in sustaining mood and emotions. The down-regulation of central beta-adrenergic and serotonergic receptors by chronic inhibition of MAO may also contribute to the antidepressant effects seen by isocarboxazid. (NCI05)" @default.
- NCIT_C47573 NCIT_NHC0 "C47573" @default.
- NCIT_C47573 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47573 NCIT_P108 "Isocarboxazid" @default.
- NCIT_C47573 NCIT_P175 "169893" @default.
- NCIT_C47573 NCIT_P207 "C0022154" @default.
- NCIT_C47573 NCIT_P210 "59-63-2" @default.
- NCIT_C47573 NCIT_P319 "34237V843T" @default.
- NCIT_C47573 NCIT_P322 "FDA" @default.
- NCIT_C47573 NCIT_P350 "C12H13N3O2" @default.
- NCIT_C47573 NCIT_P366 "Isocarboxazid" @default.
- NCIT_C47573 normalizedInformationContent "100" @default.
- NCIT_C47573 referenceCount "1" @default.
- NCIT_C47573 hasExactSynonym "3-Isoxazolecarboxylic Acid, 5-methyl-, 2-(phenylmethyl)hydrazide" @default.
- NCIT_C47573 hasExactSynonym "ISOCARBOXAZID" @default.
- NCIT_C47573 hasExactSynonym "Isocarboxazid" @default.
- NCIT_C47573 hasExactSynonym "Marplan" @default.
- NCIT_C47573 hasExactSynonym "Ro 5-0831" @default.
- NCIT_C47573 inSubset NCIT_C63923 @default.
- NCIT_C47573 type Class @default.
- NCIT_C47573 isDefinedBy ncit.owl @default.
- NCIT_C47573 label "Isocarboxazid" @default.
- NCIT_C47573 subClassOf NCIT_C1908 @default.
- NCIT_C47573 subClassOf NCIT_C1909 @default.
- NCIT_C47573 subClassOf NCIT_C265 @default.
- NCIT_C47573 subClassOf NCIT_C471 @default.
- NCIT_C47573 subClassOf NCIT_C47573 @default.
- NCIT_C47573 subClassOf NCIT_C667 @default.
- NCIT_C47573 subClassOf NCIT_C78272 @default.