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- NCIT_C47580 IAO_0000115 "The hydrochloride salt form of levalbuterol, a relatively selective sympathomimetic beta-2 adrenergic receptor agonist with bronchodilator activity. Levalbuterol hydrochloride binds to beta-2 adrenergic receptors in bronchial smooth muscle and activates intracellular adenyl cyclase, thereby increasing the production of cyclic-3', 5'-adenosine monophosphate (cAMP). Increased cAMP levels lead to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in relaxation of bronchial smooth muscles. The increased cyclic AMP concentrations also inhibit the release of inflammatory mediators from mast cells." @default.
- NCIT_C47580 NCIT_A6 NCIT_C74196 @default.
- NCIT_C47580 NCIT_NHC0 "C47580" @default.
- NCIT_C47580 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47580 NCIT_P108 "Levalbuterol Hydrochloride" @default.
- NCIT_C47580 NCIT_P207 "C0772502" @default.
- NCIT_C47580 NCIT_P210 "50293-90-8" @default.
- NCIT_C47580 NCIT_P319 "WDQ1526QJM" @default.
- NCIT_C47580 NCIT_P322 "FDA" @default.
- NCIT_C47580 NCIT_P350 "C13H21NO3.HCl" @default.
- NCIT_C47580 NCIT_P366 "Levalbuterol_Hydrochloride" @default.
- NCIT_C47580 normalizedInformationContent "100" @default.
- NCIT_C47580 referenceCount "1" @default.
- NCIT_C47580 hasExactSynonym "(-)-Salbutamol Hydrochloride" @default.
- NCIT_C47580 hasExactSynonym "1,3-Benzenedimethanol, alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Hydrochloride,(alpha1R)-" @default.
- NCIT_C47580 hasExactSynonym "LEVALBUTEROL HYDROCHLORIDE" @default.
- NCIT_C47580 hasExactSynonym "Levalbuterol Hydrochloride" @default.
- NCIT_C47580 hasExactSynonym "Xopenex" @default.
- NCIT_C47580 inSubset NCIT_C63923 @default.
- NCIT_C47580 type Class @default.
- NCIT_C47580 isDefinedBy ncit.owl @default.
- NCIT_C47580 label "Levalbuterol Hydrochloride" @default.
- NCIT_C47580 subClassOf NCIT_C1908 @default.
- NCIT_C47580 subClassOf NCIT_C1909 @default.
- NCIT_C47580 subClassOf NCIT_C29747 @default.
- NCIT_C47580 subClassOf NCIT_C47580 @default.
- NCIT_C47580 subClassOf NCIT_C48149 @default.
- NCIT_C47580 subClassOf NCIT_C78272 @default.
- NCIT_C47580 subClassOf NCIT_C87053 @default.