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- NCIT_C47589 IAO_0000115 "The etabonate salt form of loteprednol, an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity. Loteprednol etabonate exerts its effect by interacting with specific intracellular receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Loteprednol etabonate specifically induces phospholipase A2 inhibitory proteins (collectively called lipocortins), which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes." @default.
- NCIT_C47589 NCIT_NHC0 "C47589" @default.
- NCIT_C47589 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47589 NCIT_P108 "Loteprednol Etabonate" @default.
- NCIT_C47589 NCIT_P207 "C0126177" @default.
- NCIT_C47589 NCIT_P210 "82034-46-6" @default.
- NCIT_C47589 NCIT_P319 "YEH1EZ96K6" @default.
- NCIT_C47589 NCIT_P322 "FDA" @default.
- NCIT_C47589 NCIT_P350 "C24H31ClO7" @default.
- NCIT_C47589 NCIT_P366 "Loteprednol_Etabonate" @default.
- NCIT_C47589 NCIT_P368 "CHEBI:31784" @default.
- NCIT_C47589 NCIT_R122 NCIT_C16484 @default.
- NCIT_C47589 NCIT_R122 NCIT_C16486 @default.
- NCIT_C47589 NCIT_R122 NCIT_C16554 @default.
- NCIT_C47589 NCIT_R122 NCIT_C16865 @default.
- NCIT_C47589 NCIT_R122 NCIT_C16946 @default.
- NCIT_C47589 NCIT_R122 NCIT_C17021 @default.
- NCIT_C47589 NCIT_R122 NCIT_C17573 @default.
- NCIT_C47589 NCIT_R122 NCIT_C20027 @default.
- NCIT_C47589 NCIT_R122 NCIT_C26548 @default.
- NCIT_C47589 NCIT_R122 NCIT_C28459 @default.
- NCIT_C47589 normalizedInformationContent "100" @default.
- NCIT_C47589 referenceCount "1" @default.
- NCIT_C47589 hasExactSynonym "Alrex" @default.
- NCIT_C47589 hasExactSynonym "Androsta-1,4-diene-17-carboxylic Acid, 17-((ethoxycarbonyl)oxy)-11-hydroxy-3-oxo-, chloromethyl Ester,(11beta,17alpha)-" @default.
- NCIT_C47589 hasExactSynonym "LOTEPREDNOL ETABONATE" @default.
- NCIT_C47589 hasExactSynonym "Lotemax" @default.
- NCIT_C47589 hasExactSynonym "Loteprednol Etabonate" @default.
- NCIT_C47589 inSubset NCIT_C63923 @default.
- NCIT_C47589 type Class @default.
- NCIT_C47589 isDefinedBy ncit.owl @default.
- NCIT_C47589 label "Loteprednol Etabonate" @default.
- NCIT_C47589 subClassOf NCIT_C147908 @default.
- NCIT_C47589 subClassOf NCIT_C1636 @default.
- NCIT_C47589 subClassOf NCIT_C1908 @default.
- NCIT_C47589 subClassOf NCIT_C1909 @default.
- NCIT_C47589 subClassOf NCIT_C211 @default.
- NCIT_C47589 subClassOf NCIT_C2364 @default.
- NCIT_C47589 subClassOf NCIT_C308 @default.
- NCIT_C47589 subClassOf NCIT_C47589 @default.
- NCIT_C47589 subClassOf NCIT_C521 @default.
- NCIT_C47589 subClassOf NCIT_C548 @default.
- NCIT_C47589 subClassOf NCIT_C574 @default.