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- NCIT_C47591 IAO_0000115 "The acetate salt form of mafenide, a synthetic sulfonamide analog of para-aminobenzoic acid (PABA) with topical anti-infective activity. Mafenide acetate competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, thereby interferes with normal folic acid metabolism. As a result, de novo synthesis of pyrimidines, which requires folate metabolites, is impeded and subsequently DNA synthesis is affected. Mafenide acetate is bacteriostatic against many gram-negative and gram-positive organisms, including Pseudomonas aeruginosa and certain strains of anaerobes." @default.
- NCIT_C47591 NCIT_A6 NCIT_C61819 @default.
- NCIT_C47591 NCIT_NHC0 "C47591" @default.
- NCIT_C47591 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47591 NCIT_P108 "Mafenide Acetate" @default.
- NCIT_C47591 NCIT_P207 "C0024453" @default.
- NCIT_C47591 NCIT_P210 "13009-99-9" @default.
- NCIT_C47591 NCIT_P319 "RQ6LP6Z0WY" @default.
- NCIT_C47591 NCIT_P322 "FDA" @default.
- NCIT_C47591 NCIT_P350 "C7H10N2O2S.C2H4O2" @default.
- NCIT_C47591 NCIT_P366 "Mafenide_Acetate" @default.
- NCIT_C47591 normalizedInformationContent "100" @default.
- NCIT_C47591 referenceCount "1" @default.
- NCIT_C47591 hasExactSynonym "4-(Aminomethyl)benzenesulfonamide Monoacetate" @default.
- NCIT_C47591 hasExactSynonym "MAFENIDE ACETATE" @default.
- NCIT_C47591 hasExactSynonym "Mafenide Acetate" @default.
- NCIT_C47591 hasExactSynonym "Sulfamilon" @default.
- NCIT_C47591 hasExactSynonym "Sulfamylon" @default.
- NCIT_C47591 hasExactSynonym "alpha-Amino-p-toluenesulfonamide Monoacetate" @default.
- NCIT_C47591 inSubset NCIT_C63923 @default.
- NCIT_C47591 type Class @default.
- NCIT_C47591 isDefinedBy ncit.owl @default.
- NCIT_C47591 label "Mafenide Acetate" @default.
- NCIT_C47591 subClassOf NCIT_C1908 @default.
- NCIT_C47591 subClassOf NCIT_C1909 @default.
- NCIT_C47591 subClassOf NCIT_C254 @default.
- NCIT_C47591 subClassOf NCIT_C28394 @default.
- NCIT_C47591 subClassOf NCIT_C47591 @default.