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- NCIT_C47620 IAO_0000115 "The hydrochloride salt form of midodrine, a direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system." @default.
- NCIT_C47620 NCIT_A6 NCIT_C61846 @default.
- NCIT_C47620 NCIT_NHC0 "C47620" @default.
- NCIT_C47620 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47620 NCIT_P108 "Midodrine Hydrochloride" @default.
- NCIT_C47620 NCIT_P207 "C0733394" @default.
- NCIT_C47620 NCIT_P210 "3092-17-9" @default.
- NCIT_C47620 NCIT_P210 "43218-56-0" @default.
- NCIT_C47620 NCIT_P319 "59JV96YTXV" @default.
- NCIT_C47620 NCIT_P322 "FDA" @default.
- NCIT_C47620 NCIT_P350 "C12H18N2O4.HCl" @default.
- NCIT_C47620 NCIT_P366 "Midodrine_Hydrochloride" @default.
- NCIT_C47620 NCIT_P368 "CHEBI:31847" @default.
- NCIT_C47620 normalizedInformationContent "100" @default.
- NCIT_C47620 referenceCount "1" @default.
- NCIT_C47620 hasExactSynonym "(+-)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide Monohydrochloride" @default.
- NCIT_C47620 hasExactSynonym "1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol Hydrochloride" @default.
- NCIT_C47620 hasExactSynonym "Amatine" @default.
- NCIT_C47620 hasExactSynonym "Gutron" @default.
- NCIT_C47620 hasExactSynonym "MIDODRINE HYDROCHLORIDE" @default.
- NCIT_C47620 hasExactSynonym "Midamine" @default.
- NCIT_C47620 hasExactSynonym "Midodrine Hydrochloride" @default.
- NCIT_C47620 hasExactSynonym "ProAmantine" @default.
- NCIT_C47620 inSubset NCIT_C63923 @default.
- NCIT_C47620 type Class @default.
- NCIT_C47620 isDefinedBy ncit.owl @default.
- NCIT_C47620 label "Midodrine Hydrochloride" @default.
- NCIT_C47620 subClassOf NCIT_C1908 @default.
- NCIT_C47620 subClassOf NCIT_C1909 @default.
- NCIT_C47620 subClassOf NCIT_C29709 @default.
- NCIT_C47620 subClassOf NCIT_C29747 @default.
- NCIT_C47620 subClassOf NCIT_C47620 @default.
- NCIT_C47620 subClassOf NCIT_C78272 @default.
- NCIT_C47620 subClassOf NCIT_C87053 @default.