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- NCIT_C47633 IAO_0000115 "The hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides." @default.
- NCIT_C47633 NCIT_A6 NCIT_C61857 @default.
- NCIT_C47633 NCIT_NHC0 "C47633" @default.
- NCIT_C47633 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47633 NCIT_P108 "Naratriptan Hydrochloride" @default.
- NCIT_C47633 NCIT_P207 "C0594660" @default.
- NCIT_C47633 NCIT_P210 "143388-64-1" @default.
- NCIT_C47633 NCIT_P319 "10X8X4P12Z" @default.
- NCIT_C47633 NCIT_P322 "FDA" @default.
- NCIT_C47633 NCIT_P350 "C17H25N3O2S.HCl" @default.
- NCIT_C47633 NCIT_P366 "Naratriptan_Hydrochloride" @default.
- NCIT_C47633 NCIT_P368 "CHEBI:7479" @default.
- NCIT_C47633 normalizedInformationContent "100" @default.
- NCIT_C47633 referenceCount "1" @default.
- NCIT_C47633 hasExactSynonym "Amerge" @default.
- NCIT_C47633 hasExactSynonym "GR 85548A" @default.
- NCIT_C47633 hasExactSynonym "N-methyl-3-( 1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide Monohydrochloride" @default.
- NCIT_C47633 hasExactSynonym "NARATRIPTAN HYDROCHLORIDE" @default.
- NCIT_C47633 hasExactSynonym "Naratriptan Hydrochloride" @default.
- NCIT_C47633 inSubset NCIT_C63923 @default.
- NCIT_C47633 type Class @default.
- NCIT_C47633 isDefinedBy ncit.owl @default.
- NCIT_C47633 label "Naratriptan Hydrochloride" @default.
- NCIT_C47633 subClassOf NCIT_C1908 @default.
- NCIT_C47633 subClassOf NCIT_C1909 @default.
- NCIT_C47633 subClassOf NCIT_C47633 @default.
- NCIT_C47633 subClassOf NCIT_C47794 @default.
- NCIT_C47633 subClassOf NCIT_C78272 @default.