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- NCIT_C47650 IAO_0000115 "The hydrochloride salt of palonosetron, a carbazole derivative and a selective serotonin receptor antagonist with antiemetic activity. Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting. The CTZ is located in the area postrema on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle and outside the blood-brain barrier (BBB)." @default.
- NCIT_C47650 NCIT_A32 NCIT_C1909 @default.
- NCIT_C47650 NCIT_A6 NCIT_C61874 @default.
- NCIT_C47650 NCIT_NHC0 "C47650" @default.
- NCIT_C47650 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47650 NCIT_P107 "Palonosetron Hydrochloride" @default.
- NCIT_C47650 NCIT_P108 "Palonosetron Hydrochloride" @default.
- NCIT_C47650 NCIT_P207 "C1310734" @default.
- NCIT_C47650 NCIT_P210 "135729-62-3" @default.
- NCIT_C47650 NCIT_P302 "prevention of chemotherapy-induced nausea and vomiting" @default.
- NCIT_C47650 NCIT_P319 "23310D4I19" @default.
- NCIT_C47650 NCIT_P322 "CTRP" @default.
- NCIT_C47650 NCIT_P322 "FDA" @default.
- NCIT_C47650 NCIT_P322 "GDC" @default.
- NCIT_C47650 NCIT_P325 "A drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic." @default.
- NCIT_C47650 NCIT_P329 "486366" @default.
- NCIT_C47650 NCIT_P330 "486366" @default.
- NCIT_C47650 NCIT_P350 "C19H24N2O.HCl" @default.
- NCIT_C47650 NCIT_P366 "Palonosetron_Hydrochloride" @default.
- NCIT_C47650 NCIT_P375 "Palonosetron Hydrochloride" @default.
- NCIT_C47650 NCIT_P399 "486366" @default.
- NCIT_C47650 normalizedInformationContent "100" @default.
- NCIT_C47650 referenceCount "1" @default.
- NCIT_C47650 hasExactSynonym "1H-Benz(de)isoquinolin-1-one, 2-(3S)-1-azabicyclo(2.2.2)oct-3-yl-2,3,3a,4,5,6-hexahydro-, Monohydrochloride,(3aS)-" @default.
- NCIT_C47650 hasExactSynonym "Aloxi" @default.
- NCIT_C47650 hasExactSynonym "PALONOSETRON HYDROCHLORIDE" @default.
- NCIT_C47650 hasExactSynonym "Palonosetron Hydrochloride" @default.
- NCIT_C47650 hasExactSynonym "RS 25259-197" @default.
- NCIT_C47650 hasExactSynonym "palonosetron HCl" @default.
- NCIT_C47650 hasExactSynonym "palonosetron hydrochloride" @default.
- NCIT_C47650 inSubset NCIT_C116977 @default.
- NCIT_C47650 inSubset NCIT_C116978 @default.
- NCIT_C47650 inSubset NCIT_C157711 @default.
- NCIT_C47650 inSubset NCIT_C157712 @default.
- NCIT_C47650 inSubset NCIT_C176424 @default.
- NCIT_C47650 inSubset NCIT_C177537 @default.
- NCIT_C47650 inSubset NCIT_C63923 @default.
- NCIT_C47650 type Class @default.
- NCIT_C47650 isDefinedBy ncit.owl @default.
- NCIT_C47650 label "Palonosetron Hydrochloride" @default.
- NCIT_C47650 subClassOf NCIT_C1908 @default.
- NCIT_C47650 subClassOf NCIT_C1909 @default.
- NCIT_C47650 subClassOf NCIT_C267 @default.
- NCIT_C47650 subClassOf NCIT_C47650 @default.
- NCIT_C47650 subClassOf NCIT_C66885 @default.
- NCIT_C47650 subClassOf NCIT_C78272 @default.
- NCIT_C47650 subClassOf NCIT_C94726 @default.