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- NCIT_C47653 IAO_0000115 "The mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex, thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, which resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness." @default.
- NCIT_C47653 NCIT_A6 NCIT_C61879 @default.
- NCIT_C47653 NCIT_NHC0 "C47653" @default.
- NCIT_C47653 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47653 NCIT_P108 "Paroxetine Mesylate" @default.
- NCIT_C47653 NCIT_P207 "C1365510" @default.
- NCIT_C47653 NCIT_P210 "217797-14-3" @default.
- NCIT_C47653 NCIT_P319 "M711N184JE" @default.
- NCIT_C47653 NCIT_P322 "FDA" @default.
- NCIT_C47653 NCIT_P350 "C19H20FNO3.CH4O3S" @default.
- NCIT_C47653 NCIT_P366 "Paroxetine_Mesylate" @default.
- NCIT_C47653 normalizedInformationContent "100" @default.
- NCIT_C47653 referenceCount "1" @default.
- NCIT_C47653 hasExactSynonym "(-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine Mesylate" @default.
- NCIT_C47653 hasExactSynonym "PAROXETINE MESYLATE" @default.
- NCIT_C47653 hasExactSynonym "Paroxetine Mesylate" @default.
- NCIT_C47653 hasExactSynonym "Paroxetine Methanesulfonate" @default.
- NCIT_C47653 hasExactSynonym "Pexeva" @default.
- NCIT_C47653 hasExactSynonym "Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-,(3S,4R)-, Methanesulfonate" @default.
- NCIT_C47653 inSubset NCIT_C63923 @default.
- NCIT_C47653 type Class @default.
- NCIT_C47653 isDefinedBy ncit.owl @default.
- NCIT_C47653 label "Paroxetine Mesylate" @default.
- NCIT_C47653 subClassOf NCIT_C1908 @default.
- NCIT_C47653 subClassOf NCIT_C1909 @default.
- NCIT_C47653 subClassOf NCIT_C265 @default.
- NCIT_C47653 subClassOf NCIT_C47653 @default.
- NCIT_C47653 subClassOf NCIT_C78272 @default.
- NCIT_C47653 subClassOf NCIT_C94725 @default.