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- NCIT_C47668 IAO_0000115 "A hydrazine derivative and a potent non-selective monoamine oxidase (MAO) inhibitor with anxiolytic and antidepressant properties. Phenelzine sulfate irreversibly binds to MAO, thereby blocking the oxidative deamination of monoamines resulting in an increased concentration of biogenic amines and a concurrent decrease in catabolism of monoamine neurotransmitters, norepinephrine and serotonin, in the brain. In addition, through its primary metabolite phenylethylidenehyrazine (PEH), phenelzine causes elevated GABA levels in the caudate-putamen and nucleus accumbens thereby exerting its anxiolytic effects." @default.
- NCIT_C47668 NCIT_A6 NCIT_C61888 @default.
- NCIT_C47668 NCIT_NHC0 "C47668" @default.
- NCIT_C47668 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47668 NCIT_P107 "Phenelzine Sulfate" @default.
- NCIT_C47668 NCIT_P108 "Phenelzine Sulfate" @default.
- NCIT_C47668 NCIT_P175 "170957" @default.
- NCIT_C47668 NCIT_P207 "C0031393" @default.
- NCIT_C47668 NCIT_P210 "156-51-4" @default.
- NCIT_C47668 NCIT_P319 "2681D7P965" @default.
- NCIT_C47668 NCIT_P322 "CTRP" @default.
- NCIT_C47668 NCIT_P322 "FDA" @default.
- NCIT_C47668 NCIT_P329 "686546" @default.
- NCIT_C47668 NCIT_P330 "686546" @default.
- NCIT_C47668 NCIT_P350 "C8H12N2.H2O4S" @default.
- NCIT_C47668 NCIT_P366 "Phenelzine_Sulfate" @default.
- NCIT_C47668 NCIT_P399 "686546" @default.
- NCIT_C47668 normalizedInformationContent "100" @default.
- NCIT_C47668 referenceCount "1" @default.
- NCIT_C47668 hasExactSynonym "2-Phenylethylhydrazine Hydrogen Sulphate" @default.
- NCIT_C47668 hasExactSynonym "2-Phenylethylhydrazine Sulphate" @default.
- NCIT_C47668 hasExactSynonym "Nardil" @default.
- NCIT_C47668 hasExactSynonym "PHENELZINE SULFATE" @default.
- NCIT_C47668 hasExactSynonym "Phenelzine Sulfate" @default.
- NCIT_C47668 inSubset NCIT_C116977 @default.
- NCIT_C47668 inSubset NCIT_C116978 @default.
- NCIT_C47668 inSubset NCIT_C176424 @default.
- NCIT_C47668 inSubset NCIT_C63923 @default.
- NCIT_C47668 type Class @default.
- NCIT_C47668 isDefinedBy ncit.owl @default.
- NCIT_C47668 label "Phenelzine Sulfate" @default.
- NCIT_C47668 subClassOf NCIT_C1908 @default.
- NCIT_C47668 subClassOf NCIT_C1909 @default.
- NCIT_C47668 subClassOf NCIT_C471 @default.
- NCIT_C47668 subClassOf NCIT_C47668 @default.
- NCIT_C47668 subClassOf NCIT_C667 @default.