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- NCIT_C47683 IAO_0000115 "A pyrazinoisoquinoline derivative with anthelminthic property. Praziquantel increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculature through a subsequent increase in levels of calcium in the sarcoplasmic reticulum. In addition, vacuolization of the tegumental syncytium and blebbing results in tegument disintegration, leads to antigen exposure and elicit host defense responses to the worm. The result is the formation of granulomas and phagocytosis." @default.
- NCIT_C47683 NCIT_NHC0 "C47683" @default.
- NCIT_C47683 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47683 NCIT_P108 "Praziquantel" @default.
- NCIT_C47683 NCIT_P207 "C0032911" @default.
- NCIT_C47683 NCIT_P210 "55268-74-1" @default.
- NCIT_C47683 NCIT_P319 "6490C9U457" @default.
- NCIT_C47683 NCIT_P322 "FDA" @default.
- NCIT_C47683 NCIT_P350 "C19H24N2O2" @default.
- NCIT_C47683 NCIT_P366 "Praziquantel" @default.
- NCIT_C47683 NCIT_P368 "CHEBI:45267" @default.
- NCIT_C47683 normalizedInformationContent "100" @default.
- NCIT_C47683 referenceCount "1" @default.
- NCIT_C47683 hasExactSynonym "4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-" @default.
- NCIT_C47683 hasExactSynonym "Biltricide" @default.
- NCIT_C47683 hasExactSynonym "Droncit" @default.
- NCIT_C47683 hasExactSynonym "PRAZIQUANTEL" @default.
- NCIT_C47683 hasExactSynonym "Praziquantel" @default.
- NCIT_C47683 inSubset NCIT_C63923 @default.
- NCIT_C47683 type Class @default.
- NCIT_C47683 isDefinedBy ncit.owl @default.
- NCIT_C47683 label "Praziquantel" @default.
- NCIT_C47683 subClassOf NCIT_C1908 @default.
- NCIT_C47683 subClassOf NCIT_C1909 @default.
- NCIT_C47683 subClassOf NCIT_C250 @default.
- NCIT_C47683 subClassOf NCIT_C254 @default.
- NCIT_C47683 subClassOf NCIT_C276 @default.
- NCIT_C47683 subClassOf NCIT_C47683 @default.