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- NCIT_C47692 IAO_0000115 "The hydrochloride salt form of propafenone with class 1C antiarrhythmic effects. Propafenone hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby reducing sodium influx required for the initiation and conduction of impulses in Purkinje and myocardial cells. This agent produces a marked depression of phase 0 and prolonged effective refractory period in the atrio-ventricular nodal and His-Purkinje tissue, resulting in a profound decrease in excitability, conduction velocity and automaticity, thereby counteracting atrial and ventricular arrythmias." @default.
- NCIT_C47692 NCIT_A6 NCIT_C61909 @default.
- NCIT_C47692 NCIT_NHC0 "C47692" @default.
- NCIT_C47692 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47692 NCIT_P108 "Propafenone Hydrochloride" @default.
- NCIT_C47692 NCIT_P175 "37855" @default.
- NCIT_C47692 NCIT_P207 "C0700465" @default.
- NCIT_C47692 NCIT_P210 "34183-22-7" @default.
- NCIT_C47692 NCIT_P319 "33XCH0HOCD" @default.
- NCIT_C47692 NCIT_P322 "FDA" @default.
- NCIT_C47692 NCIT_P350 "C21H27NO3.HCl" @default.
- NCIT_C47692 NCIT_P366 "Propafenone_Hydrochloride" @default.
- NCIT_C47692 NCIT_P368 "CHEBI:8466" @default.
- NCIT_C47692 normalizedInformationContent "100" @default.
- NCIT_C47692 referenceCount "1" @default.
- NCIT_C47692 hasExactSynonym "1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, Hydrochloride" @default.
- NCIT_C47692 hasExactSynonym "2'-(2-Hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone Hydrochloride" @default.
- NCIT_C47692 hasExactSynonym "Baxarytmon" @default.
- NCIT_C47692 hasExactSynonym "PROPAFENONE HYDROCHLORIDE" @default.
- NCIT_C47692 hasExactSynonym "Propafenone Hydrochloride" @default.
- NCIT_C47692 hasExactSynonym "Rythmol" @default.
- NCIT_C47692 inSubset NCIT_C63923 @default.
- NCIT_C47692 type Class @default.
- NCIT_C47692 isDefinedBy ncit.owl @default.
- NCIT_C47692 label "Propafenone Hydrochloride" @default.
- NCIT_C47692 subClassOf NCIT_C1908 @default.
- NCIT_C47692 subClassOf NCIT_C1909 @default.
- NCIT_C47692 subClassOf NCIT_C47692 @default.
- NCIT_C47692 subClassOf NCIT_C47793 @default.
- NCIT_C47692 subClassOf NCIT_C78274 @default.
- NCIT_C47692 subClassOf NCIT_C93038 @default.