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- NCIT_C47699 IAO_0000115 "A synthetic benzodiazepine derivative with anxiolytic, sedative and hypnotic properties. Quazepam and its major metabolite 2-oxoquazepam potentiate gamma-aminobutyric acid (GABA) activity by binding to the benzodiazepine-1 recognition site (BZ-1) within the GABA-A receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of GABA-activated chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreased neuronal excitability." @default.
- NCIT_C47699 NCIT_NHC0 "C47699" @default.
- NCIT_C47699 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47699 NCIT_P108 "Quazepam" @default.
- NCIT_C47699 NCIT_P175 "309702" @default.
- NCIT_C47699 NCIT_P207 "C0072828" @default.
- NCIT_C47699 NCIT_P210 "36735-22-5" @default.
- NCIT_C47699 NCIT_P319 "JF8V0828ZI" @default.
- NCIT_C47699 NCIT_P322 "FDA" @default.
- NCIT_C47699 NCIT_P350 "C17H11ClF4N2S" @default.
- NCIT_C47699 NCIT_P366 "Quazepam" @default.
- NCIT_C47699 normalizedInformationContent "100" @default.
- NCIT_C47699 referenceCount "1" @default.
- NCIT_C47699 hasExactSynonym "2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-" @default.
- NCIT_C47699 hasExactSynonym "Doral" @default.
- NCIT_C47699 hasExactSynonym "Dormalin" @default.
- NCIT_C47699 hasExactSynonym "QUAZEPAM" @default.
- NCIT_C47699 hasExactSynonym "Quazepam" @default.
- NCIT_C47699 hasExactSynonym "Selepam" @default.
- NCIT_C47699 inSubset NCIT_C63923 @default.
- NCIT_C47699 type Class @default.
- NCIT_C47699 isDefinedBy ncit.owl @default.
- NCIT_C47699 label "Quazepam" @default.
- NCIT_C47699 subClassOf NCIT_C1012 @default.
- NCIT_C47699 subClassOf NCIT_C1908 @default.
- NCIT_C47699 subClassOf NCIT_C1909 @default.
- NCIT_C47699 subClassOf NCIT_C28197 @default.
- NCIT_C47699 subClassOf NCIT_C29756 @default.
- NCIT_C47699 subClassOf NCIT_C47699 @default.
- NCIT_C47699 subClassOf NCIT_C78272 @default.