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- NCIT_C47704 IAO_0000115 "A benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. While the mechanism of action of riluzole is unknown, its pharmacological activities in motor neurons include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3) interference with intracellular events that follow transmitter binding at excitatory amino acid receptors. In animal models, this agent has been shown to exhibit myorelaxant and sedative activities, apparently due to the blockade of glutamatergic neurotransmission." @default.
- NCIT_C47704 NCIT_NHC0 "C47704" @default.
- NCIT_C47704 NCIT_P106 "Organic Chemical" @default.
- NCIT_C47704 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C47704 NCIT_P107 "Riluzole" @default.
- NCIT_C47704 NCIT_P108 "Riluzole" @default.
- NCIT_C47704 NCIT_P207 "C0073379" @default.
- NCIT_C47704 NCIT_P210 "1744-22-5" @default.
- NCIT_C47704 NCIT_P319 "7LJ087RS6F" @default.
- NCIT_C47704 NCIT_P322 "CTRP" @default.
- NCIT_C47704 NCIT_P322 "FDA" @default.
- NCIT_C47704 NCIT_P325 "A drug used to treat a nerve disease called amyotrophic lateral sclerosis (ALS). It is also being studied in the treatment of melanoma (a type of skin cancer). Riluzole blocks the release of a substance that melanoma cells need to grow. It is a type of glutamate release inhibitor." @default.
- NCIT_C47704 NCIT_P329 "594943" @default.
- NCIT_C47704 NCIT_P330 "594943" @default.
- NCIT_C47704 NCIT_P350 "C8H5F3N2OS" @default.
- NCIT_C47704 NCIT_P366 "Riluzole" @default.
- NCIT_C47704 NCIT_P399 "594943" @default.
- NCIT_C47704 normalizedInformationContent "100" @default.
- NCIT_C47704 referenceCount "1" @default.
- NCIT_C47704 hasExactSynonym "2-Amino-6-(trifluoromethoxy)benzothiazole" @default.
- NCIT_C47704 hasExactSynonym "RILUZOLE" @default.
- NCIT_C47704 hasExactSynonym "Rilutek" @default.
- NCIT_C47704 hasExactSynonym "Riluzole" @default.
- NCIT_C47704 hasExactSynonym "riluzole" @default.
- NCIT_C47704 inSubset NCIT_C116977 @default.
- NCIT_C47704 inSubset NCIT_C116978 @default.
- NCIT_C47704 inSubset NCIT_C176424 @default.
- NCIT_C47704 inSubset NCIT_C63923 @default.
- NCIT_C47704 type Class @default.
- NCIT_C47704 isDefinedBy ncit.owl @default.
- NCIT_C47704 label "Riluzole" @default.
- NCIT_C47704 subClassOf NCIT_C1908 @default.
- NCIT_C47704 subClassOf NCIT_C1909 @default.
- NCIT_C47704 subClassOf NCIT_C264 @default.
- NCIT_C47704 subClassOf NCIT_C47704 @default.
- NCIT_C47704 subClassOf NCIT_C78272 @default.